Parametric linkage analysis and disequilibrium methods to identify loci for complex disease

Jeanette McClintick, D. L. Koller, N. Pankratz, S. C. Kirkwood, B. Naughton, Tatiana Foroud

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A two-step process was used to find loci contributing to the qualitative disease phenotype in the Genetic Analysis Workshop (GAW) 12 simulated data. The first step used parametric linkage analysis with a limited number of dominant and recessive models to detect linkage to chromosomal regions. Subsequently, a subset of the simulated biallelic sequence polymorphisms was used for transmission/disequilibrium tests and to build haplotypes to fine map the disease - predisposing polymorphism(s). A haplotype, strongly associated with the disease phenotype whose proximal end was within 39 base pairs of the functional allele for simulated major gene 6, was identified in the isolated population.

Original languageEnglish
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - 2001

Fingerprint

Linkage Disequilibrium
Haplotypes
Phenotype
Base Pairing
Alleles
Education
Population
Genes

Keywords

  • Association
  • Linkage
  • SNPs
  • Transmission/disequilibrium

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

McClintick, J., Koller, D. L., Pankratz, N., Kirkwood, S. C., Naughton, B., & Foroud, T. (2001). Parametric linkage analysis and disequilibrium methods to identify loci for complex disease. Genetic Epidemiology, 21(SUPPL. 1).

Parametric linkage analysis and disequilibrium methods to identify loci for complex disease. / McClintick, Jeanette; Koller, D. L.; Pankratz, N.; Kirkwood, S. C.; Naughton, B.; Foroud, Tatiana.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

McClintick, J, Koller, DL, Pankratz, N, Kirkwood, SC, Naughton, B & Foroud, T 2001, 'Parametric linkage analysis and disequilibrium methods to identify loci for complex disease', Genetic Epidemiology, vol. 21, no. SUPPL. 1.
McClintick J, Koller DL, Pankratz N, Kirkwood SC, Naughton B, Foroud T. Parametric linkage analysis and disequilibrium methods to identify loci for complex disease. Genetic Epidemiology. 2001;21(SUPPL. 1).
McClintick, Jeanette ; Koller, D. L. ; Pankratz, N. ; Kirkwood, S. C. ; Naughton, B. ; Foroud, Tatiana. / Parametric linkage analysis and disequilibrium methods to identify loci for complex disease. In: Genetic Epidemiology. 2001 ; Vol. 21, No. SUPPL. 1.
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