Paraneoplastic disorders

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Introduction Neurological paraneoplastic disorders refer to non-metastatic disorders that are not attributable to the toxicity of cancer therapy, cerebrovascular disease, coagulopathy, infection, or toxic and metabolic causes. Paraneoplastic disorders can affect any part(s) of the central (CNS) or peripheral (PNS) nervous systems (Table 17.1). Patients can be roughly grouped into those with pure or relatively pure clinical involvement of one part of the nervous system, such as cerebellar degeneration or sensory neuronopathy, and those with signs and symptoms of a diffuse and multifocal “paraneoplastic encephalomyelitis” (Dropcho, 2002; Graus et al., 2004). Several syndromes should always raise the possibility of a paraneoplastic etiology, including Lambert-Eaton myasthenic syndrome, subacute cerebellar degeneration, severe sensory neuronopathy, limbic encephalopathy, and opsoclonus-myoclonus. None of the clinical syndromes, however, have an absolute association with neoplasia, and each can occur in patients without tumors. For any paraneoplastic neurological disorder, there is a clear over-representation of one or a few particular neoplasms. Overall, small cell lung carcinoma is the tumor most often associated with paraneoplastic phenomena in adults, although the actual incidence of paraneoplastic disorders among patients with this tumor is probably no more than 1%-3%. Other tumors over-represented among adults with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, Hodgkin’s lymphoma, thymoma, and testicular germ cell tumors. Except for opsoclonus-myoclonus associated with neuroblastoma, paraneoplastic disorders in children are rare.

Original languageEnglish (US)
Title of host publicationCognition and Cancer
PublisherCambridge University Press
Number of pages19
ISBN (Electronic)9780511545900
ISBN (Print)9780521854825
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Dropcho, E. (2008). Paraneoplastic disorders. In Cognition and Cancer (pp. 239-257). Cambridge University Press.