Paraneoplastic disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Neurological paraneoplastic disorders refer to non-metastatic disorders that are not attributable to the toxicity of cancer therapy, cerebrovascular disease, coagulopathy, infection, or toxic and metabolic causes. Paraneoplastic disorders can affect any part(s) of the central (CNS) or peripheral (PNS) nervous systems (Table 17.1). Patients can be roughly grouped into those with pure or relatively pure clinical involvement of one part of the nervous system, such as cerebellar degeneration or sensory neuronopathy, and those with signs and symptoms of a diffuse and multifocal “paraneoplastic encephalomyelitis” (Dropcho, 2002; Graus et al., 2004). Several syndromes should always raise the possibility of a paraneoplastic etiology, including Lambert-Eaton myasthenic syndrome, subacute cerebellar degeneration, severe sensory neuronopathy, limbic encephalopathy, and opsoclonus-myoclonus. None of the clinical syndromes, however, have an absolute association with neoplasia, and each can occur in patients without tumors. For any paraneoplastic neurological disorder, there is a clear over-representation of one or a few particular neoplasms. Overall, small cell lung carcinoma is the tumor most often associated with paraneoplastic phenomena in adults, although the actual incidence of paraneoplastic disorders among patients with this tumor is probably no more than 1%-3%. Other tumors over-represented among adults with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, Hodgkin’s lymphoma, thymoma, and testicular germ cell tumors. Except for opsoclonus-myoclonus associated with neuroblastoma, paraneoplastic disorders in children are rare.

Original languageEnglish
Title of host publicationCognition and Cancer
PublisherCambridge University Press
Pages239-257
Number of pages19
ISBN (Print)9780511545900, 9780521854825
DOIs
StatePublished - Jan 1 2008

Fingerprint

Opsoclonus-Myoclonus Syndrome
Neoplasms
Nervous System Diseases
Nervous System Paraneoplastic Syndromes
Lambert-Eaton Myasthenic Syndrome
Cerebrovascular Disorders
Paraneoplastic Syndromes
Thymoma
Poisons
Small Cell Lung Carcinoma
Peripheral Nervous System
Brain Diseases
Hodgkin Disease
Neuroblastoma
Nervous System
Signs and Symptoms
Breast Neoplasms
Carcinoma
Incidence
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dropcho, E. (2008). Paraneoplastic disorders. In Cognition and Cancer (pp. 239-257). Cambridge University Press. https://doi.org/10.1017/CBO9780511545900.018

Paraneoplastic disorders. / Dropcho, Edward.

Cognition and Cancer. Cambridge University Press, 2008. p. 239-257.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dropcho, E 2008, Paraneoplastic disorders. in Cognition and Cancer. Cambridge University Press, pp. 239-257. https://doi.org/10.1017/CBO9780511545900.018
Dropcho E. Paraneoplastic disorders. In Cognition and Cancer. Cambridge University Press. 2008. p. 239-257 https://doi.org/10.1017/CBO9780511545900.018
Dropcho, Edward. / Paraneoplastic disorders. Cognition and Cancer. Cambridge University Press, 2008. pp. 239-257
@inbook{76577b04e45441c4ab9599b2cde2f6cd,
title = "Paraneoplastic disorders",
abstract = "Introduction Neurological paraneoplastic disorders refer to non-metastatic disorders that are not attributable to the toxicity of cancer therapy, cerebrovascular disease, coagulopathy, infection, or toxic and metabolic causes. Paraneoplastic disorders can affect any part(s) of the central (CNS) or peripheral (PNS) nervous systems (Table 17.1). Patients can be roughly grouped into those with pure or relatively pure clinical involvement of one part of the nervous system, such as cerebellar degeneration or sensory neuronopathy, and those with signs and symptoms of a diffuse and multifocal “paraneoplastic encephalomyelitis” (Dropcho, 2002; Graus et al., 2004). Several syndromes should always raise the possibility of a paraneoplastic etiology, including Lambert-Eaton myasthenic syndrome, subacute cerebellar degeneration, severe sensory neuronopathy, limbic encephalopathy, and opsoclonus-myoclonus. None of the clinical syndromes, however, have an absolute association with neoplasia, and each can occur in patients without tumors. For any paraneoplastic neurological disorder, there is a clear over-representation of one or a few particular neoplasms. Overall, small cell lung carcinoma is the tumor most often associated with paraneoplastic phenomena in adults, although the actual incidence of paraneoplastic disorders among patients with this tumor is probably no more than 1{\%}-3{\%}. Other tumors over-represented among adults with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, Hodgkin’s lymphoma, thymoma, and testicular germ cell tumors. Except for opsoclonus-myoclonus associated with neuroblastoma, paraneoplastic disorders in children are rare.",
author = "Edward Dropcho",
year = "2008",
month = "1",
day = "1",
doi = "10.1017/CBO9780511545900.018",
language = "English",
isbn = "9780511545900",
pages = "239--257",
booktitle = "Cognition and Cancer",
publisher = "Cambridge University Press",

}

TY - CHAP

T1 - Paraneoplastic disorders

AU - Dropcho, Edward

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Introduction Neurological paraneoplastic disorders refer to non-metastatic disorders that are not attributable to the toxicity of cancer therapy, cerebrovascular disease, coagulopathy, infection, or toxic and metabolic causes. Paraneoplastic disorders can affect any part(s) of the central (CNS) or peripheral (PNS) nervous systems (Table 17.1). Patients can be roughly grouped into those with pure or relatively pure clinical involvement of one part of the nervous system, such as cerebellar degeneration or sensory neuronopathy, and those with signs and symptoms of a diffuse and multifocal “paraneoplastic encephalomyelitis” (Dropcho, 2002; Graus et al., 2004). Several syndromes should always raise the possibility of a paraneoplastic etiology, including Lambert-Eaton myasthenic syndrome, subacute cerebellar degeneration, severe sensory neuronopathy, limbic encephalopathy, and opsoclonus-myoclonus. None of the clinical syndromes, however, have an absolute association with neoplasia, and each can occur in patients without tumors. For any paraneoplastic neurological disorder, there is a clear over-representation of one or a few particular neoplasms. Overall, small cell lung carcinoma is the tumor most often associated with paraneoplastic phenomena in adults, although the actual incidence of paraneoplastic disorders among patients with this tumor is probably no more than 1%-3%. Other tumors over-represented among adults with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, Hodgkin’s lymphoma, thymoma, and testicular germ cell tumors. Except for opsoclonus-myoclonus associated with neuroblastoma, paraneoplastic disorders in children are rare.

AB - Introduction Neurological paraneoplastic disorders refer to non-metastatic disorders that are not attributable to the toxicity of cancer therapy, cerebrovascular disease, coagulopathy, infection, or toxic and metabolic causes. Paraneoplastic disorders can affect any part(s) of the central (CNS) or peripheral (PNS) nervous systems (Table 17.1). Patients can be roughly grouped into those with pure or relatively pure clinical involvement of one part of the nervous system, such as cerebellar degeneration or sensory neuronopathy, and those with signs and symptoms of a diffuse and multifocal “paraneoplastic encephalomyelitis” (Dropcho, 2002; Graus et al., 2004). Several syndromes should always raise the possibility of a paraneoplastic etiology, including Lambert-Eaton myasthenic syndrome, subacute cerebellar degeneration, severe sensory neuronopathy, limbic encephalopathy, and opsoclonus-myoclonus. None of the clinical syndromes, however, have an absolute association with neoplasia, and each can occur in patients without tumors. For any paraneoplastic neurological disorder, there is a clear over-representation of one or a few particular neoplasms. Overall, small cell lung carcinoma is the tumor most often associated with paraneoplastic phenomena in adults, although the actual incidence of paraneoplastic disorders among patients with this tumor is probably no more than 1%-3%. Other tumors over-represented among adults with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, Hodgkin’s lymphoma, thymoma, and testicular germ cell tumors. Except for opsoclonus-myoclonus associated with neuroblastoma, paraneoplastic disorders in children are rare.

UR - http://www.scopus.com/inward/record.url?scp=84927051768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927051768&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511545900.018

DO - 10.1017/CBO9780511545900.018

M3 - Chapter

AN - SCOPUS:84927051768

SN - 9780511545900

SN - 9780521854825

SP - 239

EP - 257

BT - Cognition and Cancer

PB - Cambridge University Press

ER -