Paraneoplastic disorders are uncommon but clinically important complications of a large number of neoplasms. Most paraneoplastic syndromes are thought to have an autoimmune etiology, although the weight of evidence supporting autoimmunity varies among syndromes. Prompt diagnosis of a paraneoplastic disorder can increase the likelihood of a favorable neurologic and oncologic outcome. This article reviews the clinical features, autoimmune aspects, diagnostic approach, and treatment options for patients with paraneoplastic disorders affecting the spinal cord, motor neurons, neuromuscular junction, and muscle. Part 2 of this review, to be published in the next issue, will discuss the paraneoplastic neuropathies.
ASJC Scopus subject areas
- Clinical Neurology