Paraneoplastic syndromes in thymoma: An immunological perspective

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

T lymphocyte development occurs primarily during fetal life through cell-to-cell interactions with epithelial and dendritic cells. Evidence now supports the concept that thymic function continues during adulthood, which may explain why thymic neoplasms are associated with immunodeficiency and autoimmune illness. A broad variety of autoimmune conditions are observed in patients with thymic tumors, especially hematological and paraneurological syndromes, including aplastic anemia, pure red cell aplasia and myasthenia gravies, encephalomyelitis, cerebellar degeneration, sensory neuropathies, and Lambert-Eaton myasthenic syndrome. A more thorough understanding of the immunological dysfunction in patients with thymoma and thymic carcinoma promises to contribute to the overall understanding of human immunology and improve the clinical management of patients.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalCurrent Treatment Options in Oncology
Volume9
Issue number4-6
DOIs
StatePublished - Dec 1 2008

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Paraneoplastic Syndromes
Thymoma
Thymus Neoplasms
Lambert-Eaton Myasthenic Syndrome
Pure Red-Cell Aplasia
Encephalomyelitis
Aplastic Anemia
Allergy and Immunology
Cell Communication
Dendritic Cells
Epithelial Cells
T-Lymphocytes

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Paraneoplastic syndromes in thymoma : An immunological perspective. / Nelson, Robert P.; Pascuzzi, Robert M.

In: Current Treatment Options in Oncology, Vol. 9, No. 4-6, 01.12.2008, p. 269-276.

Research output: Contribution to journalReview article

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