Parathyroid hormone is associated with decreased fat mass in young healthy women

C. W. Gunther, P. A. Legowski, R. M. Lyle, C. M. Weaver, L. D. McCabe, G. P. McCabe, Munro Peacock, D. Teegarden

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition. Design: Cross-sectional and 1-year longitudinal trial. Subjects: Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months. Measurements: Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry). Results: Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R = 0.27), but not lean mass at baseline (n = 155), independent of serum calcium (corrected R = 0.25). Further, 12-month changes (n = 41) in log PTH positively predicted the 12-month change in body weight (R = 0.32) and body fat (R = 0.32), but not lean mass even when controlled for age or change in serum calcium. Conclusion: Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalInternational Journal of Obesity
Volume30
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

parathyroid hormone
Parathyroid Hormone
Fats
calcium
lipids
Dietary Calcium
Serum
body fat
Calcium
fasting
Adipose Tissue
Fasting
Body Composition
body composition
Diet Records
Body Weight Changes
dual-energy X-ray absorptiometry
body weight changes
Photon Absorptiometry
Energy Intake

Keywords

  • Body composition
  • Calcium
  • Fat mass
  • Parathyroid hormone
  • Premenopausal women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Gunther, C. W., Legowski, P. A., Lyle, R. M., Weaver, C. M., McCabe, L. D., McCabe, G. P., ... Teegarden, D. (2006). Parathyroid hormone is associated with decreased fat mass in young healthy women. International Journal of Obesity, 30(1), 94-99. https://doi.org/10.1038/sj.ijo.0803066

Parathyroid hormone is associated with decreased fat mass in young healthy women. / Gunther, C. W.; Legowski, P. A.; Lyle, R. M.; Weaver, C. M.; McCabe, L. D.; McCabe, G. P.; Peacock, Munro; Teegarden, D.

In: International Journal of Obesity, Vol. 30, No. 1, 01.2006, p. 94-99.

Research output: Contribution to journalArticle

Gunther, CW, Legowski, PA, Lyle, RM, Weaver, CM, McCabe, LD, McCabe, GP, Peacock, M & Teegarden, D 2006, 'Parathyroid hormone is associated with decreased fat mass in young healthy women', International Journal of Obesity, vol. 30, no. 1, pp. 94-99. https://doi.org/10.1038/sj.ijo.0803066
Gunther, C. W. ; Legowski, P. A. ; Lyle, R. M. ; Weaver, C. M. ; McCabe, L. D. ; McCabe, G. P. ; Peacock, Munro ; Teegarden, D. / Parathyroid hormone is associated with decreased fat mass in young healthy women. In: International Journal of Obesity. 2006 ; Vol. 30, No. 1. pp. 94-99.
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