Paraventricular Thalamus Lesions Alter Circadian Period and Activity Distribution in the Blinded Rat

M. M. Moga, R. Y. Moore

Research output: Contribution to journalArticle

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The paraventricular thalamic nucleus (PVT) is reciprocally connected with the suprachiasmatic nucleus, the mammalian circadian pacemaker. In this study, we examine the effects of PVT lesions on the free-running circadian rhythm of locomotor activity in the blinded, albino rat. In the blinded rat, lesions of the PVT cause a period lengthening of the free-running circadian rhythm and a change in the pattern of locomotor activity. In animals with complete PVT lesions, locomotor activity is concentrated in late subjective night as compared to the pre-lesion control. Our results suggest that the PVT participates in the regulation of suprachiasmatic pacemaker function and that this regulation may be modified by retinal input.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalBiological Rhythm Research
Issue number2
StatePublished - Jan 1 2000



  • Circadian rhythms
  • Locomotor activity
  • Midline thalamus
  • Retinal input
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology

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