Parental smoking and risk of childhood brain tumors

Ellen B. Gold, Alan Leviton, Ricardo Lopez, Floyd H. Gilles, Tessa Hedley-whyte, Laurence N. Kolonel, Joseph L. Lyon, G. Marie Swanson, Noel S. Weiss, Dee West, Carol Aschenbrener, Donald F. Austin

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Data from a large, population-based, case-control study were analyzed to assess the role of parental smoking in childhood brain tumors. Parents of 361 cases, newly diagnosed between January 1, 1977 and December 31, 1981 and ascertained from eight Surveillance, Epidemiology, and End Results (SEER) program registries, and 1,083 controls had been interviewed. No significant differences in risks were found to be associated with maternal or paternal smoking at any time (odds ratio (OR)=0.92 for mothers and 1.06 for fathers), during the year of birth of the child (which included both the prenatal and postnatal periods) (ORs = 0.84 for 1 pack/day for fathers), or 2 years before the child was born, i.e., the pre-conception period (ORs=0.75 for 1 pack/day for mothers, and 0.90 for 1 pack/day for fathers). Mothers were also specifically asked if they smoked during the pregnancy, and no association was found compared with never smokers (OR=1.08,95% confidence interval (Cl) 0.80-1.45) or for ever-smokers who continued to smoke during pregnancy compared with those who stopped smoking during pregnancy (OR=1.15, 95% Cl 0.75-1.78). Finally, no significant increase in risk of brain tumors was found for the child's passive exposure to parental smoking during the period from birth to diagnosis of the brain tumor in the case. The lack of an effect of parental smoking was observed for both the major histologic types and locations of brain tumors. These findings and those from earlier studies provide no support for the hypothesis that parental cigarette smoking influences the risk of brain tumors in children. Am J Epidemiol 1993;137:620-8.

Original languageEnglish (US)
Pages (from-to)620-628
Number of pages9
JournalAmerican Journal of Epidemiology
Volume137
Issue number6
StatePublished - Mar 15 1993
Externally publishedYes

Fingerprint

Brain Neoplasms
Smoking
Mothers
Fathers
Odds Ratio
Pregnancy
Parturition
SEER Program
Smoke
Registries
Case-Control Studies
Parents
Confidence Intervals
Population

Keywords

  • Brain neoplasms
  • Child
  • Environmental exposure
  • Neoplasms
  • Occurrence
  • Passive
  • Smoking

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Gold, E. B., Leviton, A., Lopez, R., Gilles, F. H., Hedley-whyte, T., Kolonel, L. N., ... Austin, D. F. (1993). Parental smoking and risk of childhood brain tumors. American Journal of Epidemiology, 137(6), 620-628.

Parental smoking and risk of childhood brain tumors. / Gold, Ellen B.; Leviton, Alan; Lopez, Ricardo; Gilles, Floyd H.; Hedley-whyte, Tessa; Kolonel, Laurence N.; Lyon, Joseph L.; Swanson, G. Marie; Weiss, Noel S.; West, Dee; Aschenbrener, Carol; Austin, Donald F.

In: American Journal of Epidemiology, Vol. 137, No. 6, 15.03.1993, p. 620-628.

Research output: Contribution to journalArticle

Gold, EB, Leviton, A, Lopez, R, Gilles, FH, Hedley-whyte, T, Kolonel, LN, Lyon, JL, Swanson, GM, Weiss, NS, West, D, Aschenbrener, C & Austin, DF 1993, 'Parental smoking and risk of childhood brain tumors', American Journal of Epidemiology, vol. 137, no. 6, pp. 620-628.
Gold EB, Leviton A, Lopez R, Gilles FH, Hedley-whyte T, Kolonel LN et al. Parental smoking and risk of childhood brain tumors. American Journal of Epidemiology. 1993 Mar 15;137(6):620-628.
Gold, Ellen B. ; Leviton, Alan ; Lopez, Ricardo ; Gilles, Floyd H. ; Hedley-whyte, Tessa ; Kolonel, Laurence N. ; Lyon, Joseph L. ; Swanson, G. Marie ; Weiss, Noel S. ; West, Dee ; Aschenbrener, Carol ; Austin, Donald F. / Parental smoking and risk of childhood brain tumors. In: American Journal of Epidemiology. 1993 ; Vol. 137, No. 6. pp. 620-628.
@article{c576eedab1dc43569cd3fd7173793fde,
title = "Parental smoking and risk of childhood brain tumors",
abstract = "Data from a large, population-based, case-control study were analyzed to assess the role of parental smoking in childhood brain tumors. Parents of 361 cases, newly diagnosed between January 1, 1977 and December 31, 1981 and ascertained from eight Surveillance, Epidemiology, and End Results (SEER) program registries, and 1,083 controls had been interviewed. No significant differences in risks were found to be associated with maternal or paternal smoking at any time (odds ratio (OR)=0.92 for mothers and 1.06 for fathers), during the year of birth of the child (which included both the prenatal and postnatal periods) (ORs = 0.84 for 1 pack/day for fathers), or 2 years before the child was born, i.e., the pre-conception period (ORs=0.75 for 1 pack/day for mothers, and 0.90 for 1 pack/day for fathers). Mothers were also specifically asked if they smoked during the pregnancy, and no association was found compared with never smokers (OR=1.08,95{\%} confidence interval (Cl) 0.80-1.45) or for ever-smokers who continued to smoke during pregnancy compared with those who stopped smoking during pregnancy (OR=1.15, 95{\%} Cl 0.75-1.78). Finally, no significant increase in risk of brain tumors was found for the child's passive exposure to parental smoking during the period from birth to diagnosis of the brain tumor in the case. The lack of an effect of parental smoking was observed for both the major histologic types and locations of brain tumors. These findings and those from earlier studies provide no support for the hypothesis that parental cigarette smoking influences the risk of brain tumors in children. Am J Epidemiol 1993;137:620-8.",
keywords = "Brain neoplasms, Child, Environmental exposure, Neoplasms, Occurrence, Passive, Smoking",
author = "Gold, {Ellen B.} and Alan Leviton and Ricardo Lopez and Gilles, {Floyd H.} and Tessa Hedley-whyte and Kolonel, {Laurence N.} and Lyon, {Joseph L.} and Swanson, {G. Marie} and Weiss, {Noel S.} and Dee West and Carol Aschenbrener and Austin, {Donald F.}",
year = "1993",
month = "3",
day = "15",
language = "English (US)",
volume = "137",
pages = "620--628",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Parental smoking and risk of childhood brain tumors

AU - Gold, Ellen B.

AU - Leviton, Alan

AU - Lopez, Ricardo

AU - Gilles, Floyd H.

AU - Hedley-whyte, Tessa

AU - Kolonel, Laurence N.

AU - Lyon, Joseph L.

AU - Swanson, G. Marie

AU - Weiss, Noel S.

AU - West, Dee

AU - Aschenbrener, Carol

AU - Austin, Donald F.

PY - 1993/3/15

Y1 - 1993/3/15

N2 - Data from a large, population-based, case-control study were analyzed to assess the role of parental smoking in childhood brain tumors. Parents of 361 cases, newly diagnosed between January 1, 1977 and December 31, 1981 and ascertained from eight Surveillance, Epidemiology, and End Results (SEER) program registries, and 1,083 controls had been interviewed. No significant differences in risks were found to be associated with maternal or paternal smoking at any time (odds ratio (OR)=0.92 for mothers and 1.06 for fathers), during the year of birth of the child (which included both the prenatal and postnatal periods) (ORs = 0.84 for 1 pack/day for fathers), or 2 years before the child was born, i.e., the pre-conception period (ORs=0.75 for 1 pack/day for mothers, and 0.90 for 1 pack/day for fathers). Mothers were also specifically asked if they smoked during the pregnancy, and no association was found compared with never smokers (OR=1.08,95% confidence interval (Cl) 0.80-1.45) or for ever-smokers who continued to smoke during pregnancy compared with those who stopped smoking during pregnancy (OR=1.15, 95% Cl 0.75-1.78). Finally, no significant increase in risk of brain tumors was found for the child's passive exposure to parental smoking during the period from birth to diagnosis of the brain tumor in the case. The lack of an effect of parental smoking was observed for both the major histologic types and locations of brain tumors. These findings and those from earlier studies provide no support for the hypothesis that parental cigarette smoking influences the risk of brain tumors in children. Am J Epidemiol 1993;137:620-8.

AB - Data from a large, population-based, case-control study were analyzed to assess the role of parental smoking in childhood brain tumors. Parents of 361 cases, newly diagnosed between January 1, 1977 and December 31, 1981 and ascertained from eight Surveillance, Epidemiology, and End Results (SEER) program registries, and 1,083 controls had been interviewed. No significant differences in risks were found to be associated with maternal or paternal smoking at any time (odds ratio (OR)=0.92 for mothers and 1.06 for fathers), during the year of birth of the child (which included both the prenatal and postnatal periods) (ORs = 0.84 for 1 pack/day for fathers), or 2 years before the child was born, i.e., the pre-conception period (ORs=0.75 for 1 pack/day for mothers, and 0.90 for 1 pack/day for fathers). Mothers were also specifically asked if they smoked during the pregnancy, and no association was found compared with never smokers (OR=1.08,95% confidence interval (Cl) 0.80-1.45) or for ever-smokers who continued to smoke during pregnancy compared with those who stopped smoking during pregnancy (OR=1.15, 95% Cl 0.75-1.78). Finally, no significant increase in risk of brain tumors was found for the child's passive exposure to parental smoking during the period from birth to diagnosis of the brain tumor in the case. The lack of an effect of parental smoking was observed for both the major histologic types and locations of brain tumors. These findings and those from earlier studies provide no support for the hypothesis that parental cigarette smoking influences the risk of brain tumors in children. Am J Epidemiol 1993;137:620-8.

KW - Brain neoplasms

KW - Child

KW - Environmental exposure

KW - Neoplasms

KW - Occurrence

KW - Passive

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0027413112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027413112&partnerID=8YFLogxK

M3 - Article

C2 - 8470663

AN - SCOPUS:0027413112

VL - 137

SP - 620

EP - 628

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -