Parenteral Nutrition for the High-Risk Neonate

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


A high proportion of extremely low birth weight (ELBW) infants experience poor growth in the neonatal intensive care unit. Nutritional deficits that rapidly accumulate shortly after birth are a major factor in these growth outcomes.Nutritional deficits can be minimized and growth outcomes improved by beginning parenteral nutrition soon after birth. Initial support should include glucose at 4-7 mg/kg per min, amino acids at 2-3 g/kg per day, and lipids at 2 g/kg per day.Goals for full parenteral nutrition support in ELBW infants are 90-100 kcal/kg per day (13-15 g/kg per day glucose, 3-4 g/kg per day lipid, 3.5-4.0 g/kg per day amino acids).There is increasing attention to fish oil-based lipid solutions, which appear to ameliorate parenteral nutrition-associated liver disease in infants that require long-term intravenous nutrition. These products are currently not commercially available in the United States. Randomized trials evaluating fish oil-based and other new parenteral nutrition solutions in preterm infants are greatly needed.

Original languageEnglish (US)
Title of host publicationAvery's Diseases of the Newborn
Subtitle of host publicationTenth Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323401722
ISBN (Print)9780323401395
StatePublished - Jan 1 2018


  • Energy
  • Glucose
  • Growth
  • Lipid
  • Parenteral nutrition
  • Protein

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Parenteral Nutrition for the High-Risk Neonate'. Together they form a unique fingerprint.

  • Cite this

    Denne, S. C. (2018). Parenteral Nutrition for the High-Risk Neonate. In Avery's Diseases of the Newborn: Tenth Edition (pp. 1023-1031.e2). Elsevier Inc..