Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations

Christina Sundal, Shinsuke Fujioka, Jay A. Van Gerpen, Christian Wider, Alexandra M. Nicholson, Matt Baker, Elizabeth A. Shuster, Jan Aasly, Salvatore Spina, Bernardino Ghetti, Sigrun Roeber, James Garbern, Alex Tselis, Russell H. Swerdlow, Bradley B. Miller, Anne Borjesson-Hanson, Ryan J. Uitti, Owen A. Ross, A. Jon Stoessl, Rosa Rademakers & 4 others Keith A. Josephs, Dennis W. Dickson, Daniel Broderick, Zbigniew K. Wszolek

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Atypical Parkinsonism associated with white matter pathology has been described in cerebrovascular diseases, mitochondrial cytopathies, osmotic demyelinating disorders, leukoencephalopathies leukodystrophies, and others. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant disorder with symptomatic onset in midlife and death within a few years after symptom onset. Neuroimaging reveals cerebral white matter lesions that are pathologically characterized by non-inflammatory myelin loss, reactive astrocytosis, and axonal spheroids. Most cases are caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. We studied neuropathologically verified HDLS patients with CSF1R mutations to assess parkinsonian features. Ten families were evaluated with 16 affected individuals. During the course of the illness, all patients had at least some degree of bradykinesia. Fifteen patients had postural instability, and seven had rigidity. Two patients initially presented with parkinsonian gait and asymmetrical bradykinesia. These two patients and two others exhibited bradykinesia, rigidity, postural instability, and tremor (two with resting) early in the course of the illness. Levodopa/carbidopa therapy in these four patients provided no benefit, and the remaining 12 patients were not treated. The mean age of onset for all patients was about 45 years (range, 18-71) and the mean disease duration was approximately six years (range, 3-11).We also reviewed HDLS patients published prior to the CSF1R discovery for the presence of parkinsonian features. Out of 50 patients, 37 had gait impairments, 8 rigidity, 7 bradykinesia, and 5 resting tremor. Our report emphasizes the presence of atypical Parkinsonism in HDLS due to CSF1R mutations.

Original languageEnglish
Pages (from-to)869-877
Number of pages9
JournalParkinsonism and Related Disorders
Volume19
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Mutation
Hypokinesia
Parkinsonian Disorders
Tremor
Gait
Hereditary Diffuse Leukoencephalopathy with Spheroids
Leukoencephalopathies
Cerebrovascular Disorders
Gliosis
Demyelinating Diseases
Myelin Sheath
Age of Onset
Neuroimaging

Keywords

  • Autosomal dominant
  • CSF1R mutation
  • HDLS
  • Parkinsonism
  • White matter disorders

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Sundal, C., Fujioka, S., Van Gerpen, J. A., Wider, C., Nicholson, A. M., Baker, M., ... Wszolek, Z. K. (2013). Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. Parkinsonism and Related Disorders, 19(10), 869-877. https://doi.org/10.1016/j.parkreldis.2013.05.013

Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. / Sundal, Christina; Fujioka, Shinsuke; Van Gerpen, Jay A.; Wider, Christian; Nicholson, Alexandra M.; Baker, Matt; Shuster, Elizabeth A.; Aasly, Jan; Spina, Salvatore; Ghetti, Bernardino; Roeber, Sigrun; Garbern, James; Tselis, Alex; Swerdlow, Russell H.; Miller, Bradley B.; Borjesson-Hanson, Anne; Uitti, Ryan J.; Ross, Owen A.; Stoessl, A. Jon; Rademakers, Rosa; Josephs, Keith A.; Dickson, Dennis W.; Broderick, Daniel; Wszolek, Zbigniew K.

In: Parkinsonism and Related Disorders, Vol. 19, No. 10, 10.2013, p. 869-877.

Research output: Contribution to journalArticle

Sundal, C, Fujioka, S, Van Gerpen, JA, Wider, C, Nicholson, AM, Baker, M, Shuster, EA, Aasly, J, Spina, S, Ghetti, B, Roeber, S, Garbern, J, Tselis, A, Swerdlow, RH, Miller, BB, Borjesson-Hanson, A, Uitti, RJ, Ross, OA, Stoessl, AJ, Rademakers, R, Josephs, KA, Dickson, DW, Broderick, D & Wszolek, ZK 2013, 'Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations', Parkinsonism and Related Disorders, vol. 19, no. 10, pp. 869-877. https://doi.org/10.1016/j.parkreldis.2013.05.013
Sundal, Christina ; Fujioka, Shinsuke ; Van Gerpen, Jay A. ; Wider, Christian ; Nicholson, Alexandra M. ; Baker, Matt ; Shuster, Elizabeth A. ; Aasly, Jan ; Spina, Salvatore ; Ghetti, Bernardino ; Roeber, Sigrun ; Garbern, James ; Tselis, Alex ; Swerdlow, Russell H. ; Miller, Bradley B. ; Borjesson-Hanson, Anne ; Uitti, Ryan J. ; Ross, Owen A. ; Stoessl, A. Jon ; Rademakers, Rosa ; Josephs, Keith A. ; Dickson, Dennis W. ; Broderick, Daniel ; Wszolek, Zbigniew K. / Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. In: Parkinsonism and Related Disorders. 2013 ; Vol. 19, No. 10. pp. 869-877.
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