Parkinson's Disease

Richard Nass, Serge Przedborski

Research output: Book/ReportBook

7 Citations (Scopus)

Abstract

Parkinsons disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. in this book, the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death will be described, as well as the opportunities that these systems provide in drug discovery.

Original languageEnglish (US)
PublisherElsevier Inc.
ISBN (Print)9780123740281
DOIs
StatePublished - 2008

Fingerprint

Parkinson Disease
Cell Death
Dopaminergic Neurons
Genetic Models
Drug Discovery
Invertebrates
Neurodegenerative Diseases
Genes
Mammals
Rodentia
Theoretical Models
Cell Culture Techniques
Research
Therapeutics

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Parkinson's Disease. / Nass, Richard; Przedborski, Serge.

Elsevier Inc., 2008.

Research output: Book/ReportBook

Nass, Richard ; Przedborski, Serge. / Parkinson's Disease. Elsevier Inc., 2008.
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