Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics

Robert B. Jones, Barbara Van Der Pol, David H. Martin, Marguerite K. Shepard

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

In vitro susceptibility testing was done on urogenital isolates of Chlamydia trachomatis from five patients, four of whom were suspected treatment failures. At least one isolate from each patient wasresistant to tetracycline at concentrations ≥8 μg/ml, although <1% of a population of organisms showed high-level resistance. Fully resistant populations selected bypassage through 8 μlml tetracycline either died or lost their resistance on further passage in antibiotic-freemedium. Relatively large inocula were required to demonstrate resistance, and morphology of inclusions was altered at high tetracycline concentrations. The observed resistance may bea new characteristic of the organism or merely newly recognized. Isolates resistant to tetracycline were resistant to doxycycline, erythromycin, sulfamethoxazole, and clindamycin but sensitive to rifampin, ciprofloxacin, and ofloxacin. Thus, resistance to tetracycline, erythromycin, and clindamycin occurs in C. trachomatis and may be a factor in some treatment failures.

Original languageEnglish (US)
Pages (from-to)1309-1315
Number of pages7
JournalJournal of Infectious Diseases
Volume162
Issue number6
DOIs
StatePublished - Dec 1990

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Chlamydia trachomatis
Tetracycline
Anti-Bacterial Agents
Clindamycin
Erythromycin
Treatment Failure
Tetracycline Resistance
Sulfamethoxazole
Ofloxacin
Doxycycline
Rifampin
Ciprofloxacin
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. / Jones, Robert B.; Der Pol, Barbara Van; Martin, David H.; Shepard, Marguerite K.

In: Journal of Infectious Diseases, Vol. 162, No. 6, 12.1990, p. 1309-1315.

Research output: Contribution to journalArticle

Jones, Robert B. ; Der Pol, Barbara Van ; Martin, David H. ; Shepard, Marguerite K. / Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. In: Journal of Infectious Diseases. 1990 ; Vol. 162, No. 6. pp. 1309-1315.
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