Partial weight bearing does not prevent musculoskeletal losses associated with disuse

Joshua M. Swift, Florence Lima, Brandon R. Macias, Matthew R. Allen, Elizabeth S. Greene, Yasaman Shirazi-Fard, Joshua S. Kupke, Harry A. Hogan, Susan A. Bloomfield

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

PURPOSE: The purpose of this study was to investigate whether partial weight-bearing activity, at either one-sixth or one-third of body mass, blunts the deleterious effects of simulated microgravity (0G) after 21 d on muscle mass and quantitative/qualitative measures of bone. METHODS: Using a novel, previously validated partial weight-bearing suspension device, mice were subjected to 16% (G/3, i.e., simulated lunar gravity) or 33% (G/6, i.e., simulated Martian gravity) weight bearing for 21 d. One gravity control (1G, i.e., Earth gravity) and tail-suspended mice (0G, i.e., simulated microgravity) served as controls to compare the effects of simulated lunar and Martian gravity to both Earth and microgravity. RESULTS: Simulated microgravity (0G) resulted in an 8% reduction in body mass and a 28% lower total plantarflexor muscle mass (for both, P < 0.01) as compared with 1G controls, but one-sixth and one-third partial weight-bearing activity attenuated losses. Relative to 1G controls, trabecular bone volume fraction (-9% to -13%) and trabecular thickness (-10% to -14%) were significantly lower in all groups (P < 0.01). In addition, cancellous and cortical bone formation rates (BFR) were lower in all reduced weight-bearing groups compared with 1G controls (-46% to -57%, trabecular BFR; -73% to -85%, cortical BFR; P < 0.001). Animals experiencing one-third but not one-sixth weight bearing exhibited attenuated deficits in femoral neck mechanical strength associated with 0G. CONCLUSION: These results suggest that partial weight bearing (up to 33% of body mass) is not sufficient to protect against bone loss observed with simulated 0 g but does mitigate reductions in soleus mass in skeletally mature female mice.

Original languageEnglish (US)
Pages (from-to)2052-2060
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume45
Issue number11
DOIs
StatePublished - Nov 1 2013

Keywords

  • Bone
  • Cancellous
  • Cortical
  • Mice
  • Microgravity
  • Skeletal Muscle

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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  • Cite this

    Swift, J. M., Lima, F., Macias, B. R., Allen, M. R., Greene, E. S., Shirazi-Fard, Y., Kupke, J. S., Hogan, H. A., & Bloomfield, S. A. (2013). Partial weight bearing does not prevent musculoskeletal losses associated with disuse. Medicine and Science in Sports and Exercise, 45(11), 2052-2060. https://doi.org/10.1249/MSS.0b013e318299c614