Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells

K. Sugita, M. J. Robertson, Y. Torimoto, J. Ritz, S. F. Schlossman, C. Morimoto

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The CD27 Ag is expressed by the majority of resting T lymphocytes and appears to play a crucial role in T cell activation. We found that some resting peripheral blood NK cells also express CD27. Furthermore, CD27 expression was up-regulated on NK cells stimulated by IL-2. The cytolytic activity of IL-2-activated, but not resting, NK cells was inhibited by an anti-CD27 mAb (anti-1A4). However, anti-1A4 did not affect conjugate formation between IL-2-activated NK cells and tumor cell targets. In contrast, anti-1A4 inhibited CD2-mediated calcium mobilization and the serine esterase activity of NK cell granules. These inhibitory effects could be mediated in part by increase in intracellular cAMP levels induced by anti- 1A4. Our results suggest that the CD27 Ag plays an important role in the regulation of activated NK cells.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
JournalJournal of Immunology
Volume149
Issue number4
StatePublished - 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Sugita, K., Robertson, M. J., Torimoto, Y., Ritz, J., Schlossman, S. F., & Morimoto, C. (1992). Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells. Journal of Immunology, 149(4), 1199-1203.