Pathogenesis of Renal Calculi

Nicole L. Miller, Andrew Evan, James E. Lingeman

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Recent reports suggest that kidney stone disease prevalence is increasing. Despite significant treatment advances, the inciting factor and sequence of events leading to kidney stone formation remain elusive; however, recent efforts to understand the pathogenesis of nephrolithiasis have led to a delineation of the human surgical anatomy, histopathology, and metabolic factors in a variety of kidney stone formers. This article reviews the fundamental concepts of calculus formation, and the leading theories of stone pathogenesis, focusing on recent data from human papillary and renal cortical biopsies in stone formers that provide evidence for the role of Randall's plaque in kidney stone disease pathogenesis. These data suggest there are individual stone-forming phenotypes with unique surgical anatomy, histology, and metabolic profiles.

Original languageEnglish
Pages (from-to)295-313
Number of pages19
JournalUrologic Clinics of North America
Volume34
Issue number3
DOIs
StatePublished - Aug 2007

Fingerprint

Kidney Calculi
Kidney Diseases
Anatomy
Concept Formation
Nephrolithiasis
Metabolome
Calculi
Histology
Phenotype
Kidney
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Pathogenesis of Renal Calculi. / Miller, Nicole L.; Evan, Andrew; Lingeman, James E.

In: Urologic Clinics of North America, Vol. 34, No. 3, 08.2007, p. 295-313.

Research output: Contribution to journalArticle

Miller, Nicole L. ; Evan, Andrew ; Lingeman, James E. / Pathogenesis of Renal Calculi. In: Urologic Clinics of North America. 2007 ; Vol. 34, No. 3. pp. 295-313.
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