Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm)

Marion J J Gijbels, Chris Zurcher, Georg Kraal, Graham R. Elliott, Harm HogenEsch, Gerrit Schijff, Huub F J Savelkoul, Piet L B Bruijnzeel

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Chronic proliferative dermatitis is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm), showing alopecia, epithelial hyperproliferation, infiltration by eosinophils and macrophages, and vascular dilatation. To further elucidate its pathogenesis, organs of 1-, 2-, 3-, 4-, 5-, and 6-week-old cpdm/cpdm mice were examined. At 4 weeks, the epidermal thickness was increased, whereas already at 3 weeks, the bromodeoxyuridine incorporation was increased in the basal keratinocytes. However, already at the age of 1 week, skin, lungs, and lymph nodes were infiltrated by eosinophils although no macroscopic lesions were present. Compared with control animals, 6-week-old cpdm/cpdm mice had decreased serum IgE levels and increased numbers of mast cells. From the age of 1 week these mast cells became increasingly IgE positive. In contrast, the mast cells of the control animals remained IgE negative. Mast cells of control and cpdm/cpdm mice were interleukin-4 and tumor necrosis factor-α positive. A likely explanation for the tissue infiltration of eosinophils could be the release of interleukin-4 and tumor necrosis factor-α from activated mast cells. Tumor necrosis factor-α may lead to the expression of E-selectin on endothelial cells, facilitating interleukin-4-mediated eosinophil transendothelial migration. Although various pathogenetic aspects of the cpdm/cpdm mouse need further elucidation, this model can be a tool to study eosinophil infiltration, leukocyte-endothelial cell interactions, and mast cell proliferation. Furthermore, the cpdm/cpdm mouse can be used to study chronic inflammatory skin disease because of the severe epidermal proliferation.

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalAmerican Journal of Pathology
Volume148
Issue number3
StatePublished - Mar 1996
Externally publishedYes

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Dermatitis
Mast Cells
Eosinophils
Skin
Interleukin-4
Immunoglobulin E
Tumor Necrosis Factor-alpha
Endothelial Cells
Transendothelial and Transepithelial Migration
E-Selectin
Alopecia
Bromodeoxyuridine
Inbred C57BL Mouse
Keratinocytes
Skin Diseases
Cell Communication
Blood Vessels
Dilatation
Leukocytes
Lymph Nodes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Gijbels, M. J. J., Zurcher, C., Kraal, G., Elliott, G. R., HogenEsch, H., Schijff, G., ... Bruijnzeel, P. L. B. (1996). Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). American Journal of Pathology, 148(3), 941-950.

Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). / Gijbels, Marion J J; Zurcher, Chris; Kraal, Georg; Elliott, Graham R.; HogenEsch, Harm; Schijff, Gerrit; Savelkoul, Huub F J; Bruijnzeel, Piet L B.

In: American Journal of Pathology, Vol. 148, No. 3, 03.1996, p. 941-950.

Research output: Contribution to journalArticle

Gijbels, MJJ, Zurcher, C, Kraal, G, Elliott, GR, HogenEsch, H, Schijff, G, Savelkoul, HFJ & Bruijnzeel, PLB 1996, 'Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm)', American Journal of Pathology, vol. 148, no. 3, pp. 941-950.
Gijbels MJJ, Zurcher C, Kraal G, Elliott GR, HogenEsch H, Schijff G et al. Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). American Journal of Pathology. 1996 Mar;148(3):941-950.
Gijbels, Marion J J ; Zurcher, Chris ; Kraal, Georg ; Elliott, Graham R. ; HogenEsch, Harm ; Schijff, Gerrit ; Savelkoul, Huub F J ; Bruijnzeel, Piet L B. / Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). In: American Journal of Pathology. 1996 ; Vol. 148, No. 3. pp. 941-950.
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