Pathogenesis of stone disease

Elaine M. Worcester, Andrew Evan, Fredric L. Coe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

All stones share similar presenting symptoms, and urine supersaturation with respect to the mineral phase of the stone is essential for stone formation. However, recent studies using papillary biopsies of stone formers provide a view of the histology of renal crystal deposition which suggests that the early sequence of events leading to stone formation may differ depending on the type of stone and on the urine chemistry leading to supersaturation. Three general patterns of crystal deposition are seen: interstitial apatite plaque in idiopathic calcium oxalate stone formers, which is the site of stone attachment; tubule deposition of apatite, seen in all calcium phosphate stone formers; and mixtures of apatite and another crystal phase, such as cystine or calcium oxalate, seen in patients with cystinuria or enteric hyperoxaluria. The presence of apatite crystal in either the interstitial or tubule compartment (and sometimes both) of the renal medulla in stone formers is the rule, and has implications for the initial steps of stone formation and the potential for renal injury.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages3-13
Number of pages11
Volume1049
DOIs
StatePublished - 2008
Event2nd International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Apr 17 2008Apr 18 2008

Other

Other2nd International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period4/17/084/18/08

Fingerprint

pathogenesis
rocks
apatites
urine
oxalates
supersaturation
crystals
calcium
interstitials
calcium phosphates
histology
compartments
attachment
minerals
chemistry

Keywords

  • Calcium oxalate
  • Calcium phosphate
  • Nephrolithiasis
  • Randall's plaque

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Worcester, E. M., Evan, A., & Coe, F. L. (2008). Pathogenesis of stone disease. In AIP Conference Proceedings (Vol. 1049, pp. 3-13) https://doi.org/10.1063/1.2998058

Pathogenesis of stone disease. / Worcester, Elaine M.; Evan, Andrew; Coe, Fredric L.

AIP Conference Proceedings. Vol. 1049 2008. p. 3-13.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Worcester, EM, Evan, A & Coe, FL 2008, Pathogenesis of stone disease. in AIP Conference Proceedings. vol. 1049, pp. 3-13, 2nd International Urolithiasis Research Symposium, Indianapolis, IN, United States, 4/17/08. https://doi.org/10.1063/1.2998058
Worcester EM, Evan A, Coe FL. Pathogenesis of stone disease. In AIP Conference Proceedings. Vol. 1049. 2008. p. 3-13 https://doi.org/10.1063/1.2998058
Worcester, Elaine M. ; Evan, Andrew ; Coe, Fredric L. / Pathogenesis of stone disease. AIP Conference Proceedings. Vol. 1049 2008. pp. 3-13
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