Pathologic features the urologist should expect on a prostate biopsy

Mingxin Che, Wael Sakr, David Grignon

Research output: Contribution to journalArticle

12 Scopus citations


In recent years, the pathological evaluation of prostate biopsy specimens has made great improvements in diagnostic accuracy and comprehensiveness. In this article, we review major pathological findings on prostate biopsy, their interpretation and reporting, as well as their clinical significance and utility. We discuss especially the clinically relevant histological features in either a positive or negative biopsy. We emphasize that both Gleason score and extent of cancer involvement in a needle core biopsy are important predictors of clinical outcome after either radical prostatectomy or radiation. Special issues regarding diagnosis and grading of minimal cancer on needle core biopsies are discussed. We also highlight the current standards on high-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation on needle core biopsies. In summary, the pathology reports on needle biopsies are far beyond the simple presence or absence of cancer; they contain invaluable information to clinicians on patient management and counseling.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalUrologic Oncology: Seminars and Original Investigations
Issue number2
StatePublished - Mar 1 2003


  • Atypical small acinar proliferation
  • High-grade prostatic intraepithelial neoplasia
  • Minimal cancer
  • Prostate biopsy
  • Repeat biopsy

ASJC Scopus subject areas

  • Oncology
  • Urology

Fingerprint Dive into the research topics of 'Pathologic features the urologist should expect on a prostate biopsy'. Together they form a unique fingerprint.

  • Cite this