Pathological Upgrading and Up Staging With Immediate Repeat Biopsy in Patients Eligible for Active Surveillance

Ryan K. Berglund, Timothy Masterson, Kinjal C. Vora, Scott E. Eggener, James A. Eastham, Bertrand D. Guillonneau

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Purpose: Active surveillance with selective delayed intervention is a treatment regimen used in patients with low risk prostate cancer. Decision making is based on pretreatment prostate specific antigen, clinical stage and prostate biopsy results. We reviewed our experience with immediate repeat biopsy in patients eligible for active surveillance with selective delayed intervention. Materials and Methods: A retrospective review was done of the records of consecutive patients who underwent repeat biopsy within 3 months of a first positive biopsy from March 2002 to June 2007. Patients were considered eligible if they had prostate specific antigen less than 10 ng/ml, clinical stage T2a or less, Gleason pattern 3 or less, 3 or fewer positive cores and no single core with 50% or greater cancer involvement. Results: A total of 104 patients met eligibility criteria. Of the 104 repeat biopsies performed 27 (26%) were negative, 59 (57%) had a Gleason score of 6 or less and 17 (16%) had a Gleason score of 7. One patient had a Gleason score of 9, while 10 of 104 (10%) had greater than 3 cores involved on repeat biopsy and 12 (12%) had 50% or greater involvement of at least 1 core. Of 104 cases (27%) 28 were upgraded and/or up staged. Treated cases that were upgraded and/or up staged were more likely to show higher pathological stage and grade at radical prostatectomy than those that were not (p = 0.003 and p = 0.001, respectively). Conclusions: Immediate repeat biopsy in cases of active surveillance with selective delayed intervention resulted in 27% being upgraded or up staged and those were more likely to show higher grade and stage disease at radical prostatectomy. We recommend repeat biopsy because it improved our discrimination of who are the best candidates for active surveillance with selective delayed intervention.

Original languageEnglish (US)
Pages (from-to)1964-1968
Number of pages5
JournalJournal of Urology
Volume180
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

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Biopsy
Neoplasm Grading
Prostate-Specific Antigen
Prostatectomy
Prostate
Prostatic Neoplasms
Decision Making
Neoplasms

Keywords

  • biopsy
  • neoplasm staging
  • prostate
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Pathological Upgrading and Up Staging With Immediate Repeat Biopsy in Patients Eligible for Active Surveillance. / Berglund, Ryan K.; Masterson, Timothy; Vora, Kinjal C.; Eggener, Scott E.; Eastham, James A.; Guillonneau, Bertrand D.

In: Journal of Urology, Vol. 180, No. 5, 11.2008, p. 1964-1968.

Research output: Contribution to journalArticle

Berglund, Ryan K. ; Masterson, Timothy ; Vora, Kinjal C. ; Eggener, Scott E. ; Eastham, James A. ; Guillonneau, Bertrand D. / Pathological Upgrading and Up Staging With Immediate Repeat Biopsy in Patients Eligible for Active Surveillance. In: Journal of Urology. 2008 ; Vol. 180, No. 5. pp. 1964-1968.
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abstract = "Purpose: Active surveillance with selective delayed intervention is a treatment regimen used in patients with low risk prostate cancer. Decision making is based on pretreatment prostate specific antigen, clinical stage and prostate biopsy results. We reviewed our experience with immediate repeat biopsy in patients eligible for active surveillance with selective delayed intervention. Materials and Methods: A retrospective review was done of the records of consecutive patients who underwent repeat biopsy within 3 months of a first positive biopsy from March 2002 to June 2007. Patients were considered eligible if they had prostate specific antigen less than 10 ng/ml, clinical stage T2a or less, Gleason pattern 3 or less, 3 or fewer positive cores and no single core with 50{\%} or greater cancer involvement. Results: A total of 104 patients met eligibility criteria. Of the 104 repeat biopsies performed 27 (26{\%}) were negative, 59 (57{\%}) had a Gleason score of 6 or less and 17 (16{\%}) had a Gleason score of 7. One patient had a Gleason score of 9, while 10 of 104 (10{\%}) had greater than 3 cores involved on repeat biopsy and 12 (12{\%}) had 50{\%} or greater involvement of at least 1 core. Of 104 cases (27{\%}) 28 were upgraded and/or up staged. Treated cases that were upgraded and/or up staged were more likely to show higher pathological stage and grade at radical prostatectomy than those that were not (p = 0.003 and p = 0.001, respectively). Conclusions: Immediate repeat biopsy in cases of active surveillance with selective delayed intervention resulted in 27{\%} being upgraded or up staged and those were more likely to show higher grade and stage disease at radical prostatectomy. We recommend repeat biopsy because it improved our discrimination of who are the best candidates for active surveillance with selective delayed intervention.",
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