Pathology of flat bladder lesions with emphasis on putative precursors

Liang Cheng, Darrell Davidson, Sean R. Williamson, Gregory T. MacLennan, Robert Emerson, Rodolfo Montironi, Antonio Lopez-Beltran

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Flat bladder lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Differentiating these lesions is important because of differences in patient management and clinical outcome. The precise nature of precursor lesions of bladder cancer remains incompletely understood. Urothelial CIS is the most definitely characterized precursor lesion of high grade bladder cancer. Atypia of unknown significance (AUS) is somewhat controversial. For practical purposes, AUS and reactive urothelial changes should be considered a single entity, since neither lesion has established preneoplastic potential. Simple hyperplasia and papillary hyperplasia are recently identified putative preneoplastic lesions. More recent molecular data also support the precursor nature of intestinal metaplasia and keratinizing squamous metaplasia. In this review, we also discuss the utility of molecular ancillary studies in establishing premalignant lesions, diagnosis, and differential diagnosis of flat bladder lesions.

Original languageEnglish
Pages (from-to)355-365
Number of pages11
JournalDiagnostic Histopathology
Volume19
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Carcinoma in Situ
Metaplasia
Urinary Bladder Neoplasms
Hyperplasia
Urinary Bladder
Pathology
Differential Diagnosis

Keywords

  • Atypia of unknown significance
  • Bladder
  • Flat lesions
  • Molecular pathogenesis
  • Precursors
  • Urothelial carcinoma in situ
  • Urothelial dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Cheng, L., Davidson, D., Williamson, S. R., MacLennan, G. T., Emerson, R., Montironi, R., & Lopez-Beltran, A. (2013). Pathology of flat bladder lesions with emphasis on putative precursors. Diagnostic Histopathology, 19(10), 355-365. https://doi.org/10.1016/j.mpdhp.2013.08.003

Pathology of flat bladder lesions with emphasis on putative precursors. / Cheng, Liang; Davidson, Darrell; Williamson, Sean R.; MacLennan, Gregory T.; Emerson, Robert; Montironi, Rodolfo; Lopez-Beltran, Antonio.

In: Diagnostic Histopathology, Vol. 19, No. 10, 10.2013, p. 355-365.

Research output: Contribution to journalArticle

Cheng, L, Davidson, D, Williamson, SR, MacLennan, GT, Emerson, R, Montironi, R & Lopez-Beltran, A 2013, 'Pathology of flat bladder lesions with emphasis on putative precursors', Diagnostic Histopathology, vol. 19, no. 10, pp. 355-365. https://doi.org/10.1016/j.mpdhp.2013.08.003
Cheng, Liang ; Davidson, Darrell ; Williamson, Sean R. ; MacLennan, Gregory T. ; Emerson, Robert ; Montironi, Rodolfo ; Lopez-Beltran, Antonio. / Pathology of flat bladder lesions with emphasis on putative precursors. In: Diagnostic Histopathology. 2013 ; Vol. 19, No. 10. pp. 355-365.
@article{10040d414106465587fbea7bbe3e8c6d,
title = "Pathology of flat bladder lesions with emphasis on putative precursors",
abstract = "Flat bladder lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Differentiating these lesions is important because of differences in patient management and clinical outcome. The precise nature of precursor lesions of bladder cancer remains incompletely understood. Urothelial CIS is the most definitely characterized precursor lesion of high grade bladder cancer. Atypia of unknown significance (AUS) is somewhat controversial. For practical purposes, AUS and reactive urothelial changes should be considered a single entity, since neither lesion has established preneoplastic potential. Simple hyperplasia and papillary hyperplasia are recently identified putative preneoplastic lesions. More recent molecular data also support the precursor nature of intestinal metaplasia and keratinizing squamous metaplasia. In this review, we also discuss the utility of molecular ancillary studies in establishing premalignant lesions, diagnosis, and differential diagnosis of flat bladder lesions.",
keywords = "Atypia of unknown significance, Bladder, Flat lesions, Molecular pathogenesis, Precursors, Urothelial carcinoma in situ, Urothelial dysplasia",
author = "Liang Cheng and Darrell Davidson and Williamson, {Sean R.} and MacLennan, {Gregory T.} and Robert Emerson and Rodolfo Montironi and Antonio Lopez-Beltran",
year = "2013",
month = "10",
doi = "10.1016/j.mpdhp.2013.08.003",
language = "English",
volume = "19",
pages = "355--365",
journal = "Diagnostic Histopathology",
issn = "1756-2317",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - Pathology of flat bladder lesions with emphasis on putative precursors

AU - Cheng, Liang

AU - Davidson, Darrell

AU - Williamson, Sean R.

AU - MacLennan, Gregory T.

AU - Emerson, Robert

AU - Montironi, Rodolfo

AU - Lopez-Beltran, Antonio

PY - 2013/10

Y1 - 2013/10

N2 - Flat bladder lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Differentiating these lesions is important because of differences in patient management and clinical outcome. The precise nature of precursor lesions of bladder cancer remains incompletely understood. Urothelial CIS is the most definitely characterized precursor lesion of high grade bladder cancer. Atypia of unknown significance (AUS) is somewhat controversial. For practical purposes, AUS and reactive urothelial changes should be considered a single entity, since neither lesion has established preneoplastic potential. Simple hyperplasia and papillary hyperplasia are recently identified putative preneoplastic lesions. More recent molecular data also support the precursor nature of intestinal metaplasia and keratinizing squamous metaplasia. In this review, we also discuss the utility of molecular ancillary studies in establishing premalignant lesions, diagnosis, and differential diagnosis of flat bladder lesions.

AB - Flat bladder lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Differentiating these lesions is important because of differences in patient management and clinical outcome. The precise nature of precursor lesions of bladder cancer remains incompletely understood. Urothelial CIS is the most definitely characterized precursor lesion of high grade bladder cancer. Atypia of unknown significance (AUS) is somewhat controversial. For practical purposes, AUS and reactive urothelial changes should be considered a single entity, since neither lesion has established preneoplastic potential. Simple hyperplasia and papillary hyperplasia are recently identified putative preneoplastic lesions. More recent molecular data also support the precursor nature of intestinal metaplasia and keratinizing squamous metaplasia. In this review, we also discuss the utility of molecular ancillary studies in establishing premalignant lesions, diagnosis, and differential diagnosis of flat bladder lesions.

KW - Atypia of unknown significance

KW - Bladder

KW - Flat lesions

KW - Molecular pathogenesis

KW - Precursors

KW - Urothelial carcinoma in situ

KW - Urothelial dysplasia

UR - http://www.scopus.com/inward/record.url?scp=84885912381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885912381&partnerID=8YFLogxK

U2 - 10.1016/j.mpdhp.2013.08.003

DO - 10.1016/j.mpdhp.2013.08.003

M3 - Article

AN - SCOPUS:84885912381

VL - 19

SP - 355

EP - 365

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

SN - 1756-2317

IS - 10

ER -