Pathology of renal cell carcinoma an update

Antonio Lopez-Beltran, Liang Cheng, Alfredo Vidal, Marina Scarpelli, Ziya Kirkali, Ana Blanca, Rodolfo Montironi

Research output: Contribution to journalArticle

18 Scopus citations


The use of classic and newer methodologies, including histopathology, electron microscopy, immunohistochemistry, cytogenetics, and molecular diagnostic techniques, has greatly influenced distinctions between various types of renal carcinoma. The most recent World Health Organization classification of renal neoplasms encompassed nearly 50 distinctive renal neoplasms. These categories have been expanded during recent years, incorporating newer histotypes, thus suggesting that the next revision of this classification will incorporate some of the recently recognized entities. In this review we examine the clinicopathologic and genetic features of renal carcinomas most often seen in clinical practice. Emphasis is placed on defining risk categories by incorporating pathologic predictive parameters and tumor histotypes. Since pathology of renal cell cancer is a rapidly evolving field, we also include brief comments on newer tumor variants for which there currently is not enough clinicopathologic information to permit classification as distinctive tumor histotypes. (Anal Quant Cytopathol Histopathol 2013;35:61-76).

Original languageEnglish (US)
Pages (from-to)61-76
Number of pages16
JournalAnalytical and Quantitative Cytology and Histology
Issue number2
StatePublished - Apr 1 2013


  • Classification
  • Genetics
  • Pathology
  • Prognosis
  • Renal cancer
  • Renal cell carcinoma
  • Variants

ASJC Scopus subject areas

  • Anatomy
  • Histology

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  • Cite this

    Lopez-Beltran, A., Cheng, L., Vidal, A., Scarpelli, M., Kirkali, Z., Blanca, A., & Montironi, R. (2013). Pathology of renal cell carcinoma an update. Analytical and Quantitative Cytology and Histology, 35(2), 61-76.