Pathology of the adenoma-carcinoma sequence: From aberrant crypt focus to invasive carcinoma

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The adenoma-carcinoma sequence postulates that colorectal carcinomas arise from precursor lesions, called adenomas. All adenomas contain dysplastic epithelium that arises from mutations in either the adenomatous polyposis coli gene or DNA mismatch repair genes. The earliest lesion detected with dysplasia is the aberrant crypt focus. Over time, as this lesion acquires additional mutations, it evolves into a classic adenomatous polyp. Adenomatous polyps are classified as tubular, tubulovillous, or villous. Generally, as polyps increase in size, the degree of dysplasia worsens, the villous component increases, the number of genetic abnormalities increases, and the likelihood of harboring invasive carcinoma increases. Carcinomas associated with DNA mismatch repair mutations are more likely to be poorly differentiated and incite a host lymphocytic response. These tumors seem to have a better prognosis, stage for stage, than typical colorectal carcinomas. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalSeminars in Gastrointestinal Disease
Volume11
Issue number4
StatePublished - Jan 1 2000

Fingerprint

Aberrant Crypt Foci
Adenoma
Adenomatous Polyps
DNA Mismatch Repair
Pathology
Carcinoma
Mutation
Colorectal Neoplasms
APC Genes
Polyps
Epithelium
Genes
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pathology of the adenoma-carcinoma sequence : From aberrant crypt focus to invasive carcinoma. / Cummings, O. W.

In: Seminars in Gastrointestinal Disease, Vol. 11, No. 4, 01.01.2000, p. 229-237.

Research output: Contribution to journalReview article

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