Pathophysiological basis for the treatment of chronic obstructive pulmonary disease

Cynthia Brown, Robert A. Wise

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews the treatment of chronic obstructive pulmonary disease (COPD) based on the pathophysiological alterations that occur in this disease. We do not intend for this chapter to substitute for formal, expertconsensus evidence-based guidelines for the treatment of COPDsuch as those that have been produced by the National Heart, Lung and Blood Institute (NHLBI)/World Health Organization (WHO) Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop (1) or the excellent systematic evidence-based reviews of the Cochrane Collaboration (2). Our intent is instead to organize the approach to the therapy of COPD based on an understanding of the biological and physiological abnormalities that characterize the disease. Therefore, the chapter addresses the use of bronchodilators in the context of airways reactivity, oxygen supplementation in the context of gas exchange abnormalities, antibiotics and the role of infection, and antiinflammatory treatments in the context of what is known about inflammatory changes in COPD. We point out important gaps in our knowledge to focus future research directions for the treatment of COPD.

Original languageEnglish (US)
Title of host publicationLung Development and Regeneration
PublisherCRC Press
Pages115-147
Number of pages33
ISBN (Electronic)9781420030532
ISBN (Print)9780824754396
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Brown, C., & Wise, R. A. (2004). Pathophysiological basis for the treatment of chronic obstructive pulmonary disease. In Lung Development and Regeneration (pp. 115-147). CRC Press.