Pathophysiology of arrhythmias: Clinical electrophysiology

Douglas P. Zipes, James J. Heger, Eric N. Prystowsky

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We have endeavored to relate known electrophysiologic mechanisms of arrhythmia development to clinically occurring arrhythmias, realizing that definitive conclusions can only be surmised at present. Arrhythmias that may be due to disorders of impulse formation include slow atrial, junctional, and ventricular escape rhythms, certain types of atrial tachycardias (such as those produced by digitalis), accelerated junctional (nonparoxysmal junctional tachycardia) and idioventricular rhythms, and parasystole. Arrhythmias that may be due to disorders of impulse conduction include flutter and fibrillation, atrioventricular nodal reentrant tachycardia, reciprocating tachycardias associated with an accessory pathway, sinus nodal reentry, some atrial tachycardias, and many ventricular tachycardias. Understanding the mechanism of the tachycardia, in some instances, helps direct rational therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)812-828
Number of pages17
JournalAmerican Heart Journal
Issue number4 PART 2
StatePublished - Oct 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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