Pathophysiology of Bone Metastases

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bone metastases are a late event in tumor progression, contributing to morbidity and mortality and decreasing patient quality of life. Cancer colonization of the skeleton is characteristic of advanced tumors of breast, prostate and other sites and of multiple myeloma. The pathophysiology of cancer in the skeleton can be conceptualized as a vicious cycle, where cancer-secreted factors activate bone cells to release factors that encourage further growth of tumor, which in turn secretes more factors into the microenvironment. Bone provides unusual physical conditions favorable to tumor growth: low pH and oxygen tension and high concentrations of calcium, phosphate and many growth factors. It also houses stem cells, bone marrow and immune cells, which can encourage the establishment, growth and survival of metastases. A plethora of bone and tumor factors contributes to the vicious cycle: too many to be individually targeted in the clinic. However, inhibition of bone resorption is invariably effective and may oppose the initial development of cancer in bone. Central pathways, such as hypoxia and TGFβ signaling, are important for both tumor and bone functions; they are promising targets for improved therapies, while other pathways may yield future treatments to decrease bone metastases and myeloma bone disease.

Original languageEnglish
Title of host publicationCancer Metastasis - Biology and Treatment
Pages3-17
Number of pages15
Volume21
Edition1
DOIs
StatePublished - 2014

Publication series

NameCancer Metastasis - Biology and Treatment
Number1
Volume21
ISSN (Print)15682102

Fingerprint

Neoplasm Metastasis
Bone and Bones
Neoplasms
Skeleton
Growth
Bone Neoplasms
Bone Diseases
Bone Resorption
Multiple Myeloma
Bone Marrow Cells
Prostate
Intercellular Signaling Peptides and Proteins
Stem Cells
Quality of Life
Breast Neoplasms
Oxygen
Morbidity
Survival
Mortality
Therapeutics

Keywords

  • Bone metastasis
  • Bone resorption
  • Multiple myeloma
  • Osteoblast
  • Osteoclast
  • Osteocyte
  • Vicious cycle

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chirgwin, J., & Roodman, G. D. (2014). Pathophysiology of Bone Metastases. In Cancer Metastasis - Biology and Treatment (1 ed., Vol. 21, pp. 3-17). (Cancer Metastasis - Biology and Treatment; Vol. 21, No. 1). https://doi.org/10.1007/978-94-007-7569-5_1

Pathophysiology of Bone Metastases. / Chirgwin, John; Roodman, G. David.

Cancer Metastasis - Biology and Treatment. Vol. 21 1. ed. 2014. p. 3-17 (Cancer Metastasis - Biology and Treatment; Vol. 21, No. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chirgwin, J & Roodman, GD 2014, Pathophysiology of Bone Metastases. in Cancer Metastasis - Biology and Treatment. 1 edn, vol. 21, Cancer Metastasis - Biology and Treatment, no. 1, vol. 21, pp. 3-17. https://doi.org/10.1007/978-94-007-7569-5_1
Chirgwin J, Roodman GD. Pathophysiology of Bone Metastases. In Cancer Metastasis - Biology and Treatment. 1 ed. Vol. 21. 2014. p. 3-17. (Cancer Metastasis - Biology and Treatment; 1). https://doi.org/10.1007/978-94-007-7569-5_1
Chirgwin, John ; Roodman, G. David. / Pathophysiology of Bone Metastases. Cancer Metastasis - Biology and Treatment. Vol. 21 1. ed. 2014. pp. 3-17 (Cancer Metastasis - Biology and Treatment; 1).
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