Pathophysiology of Vascular Calcification

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Vascular calcification can lead to cardiovascular morbidity and mortality. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The pathogenesis of vascular calcification is complex and involves a transformation of vascular smooth muscle cells to an osteo/chondrocytic cell that expresses RUNX2 and produces matrix vesicles. The imbalance of promoters (such as hyperphosphatemia and hypercalcemia) and inhibitors (e.g., fetuin-A) is critical in the development of vascular calcification. The altered mineral metabolism and deficiency in inhibitors are common in patients with chronic kidney disease (CKD) and is one reason why vascular calcification is so prevalent in that population.

Original languageEnglish (US)
Pages (from-to)372-380
Number of pages9
JournalCurrent Osteoporosis Reports
Volume13
Issue number6
DOIs
StatePublished - Sep 26 2015

Keywords

  • Calcification
  • Vascular calcification
  • Vascular smooth muscle cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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