Pathways of antigen processing

Janice S. Blum, Pamela A. Wearsch, Peter Cresswell

Research output: Contribution to journalReview articlepeer-review

635 Scopus citations

Abstract

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I-and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar processing of self proteins is necessary to establish and maintain tolerance. Cells use a variety of mechanisms to acquire protein antigens, from translation in the cytosol to variations on the theme of endocytosis, and to degrade them once acquired. In this review, we highlight the aspects of MHC-I and MHC-II biosynthesis and assembly that have evolved to intersect these pathways and sample the peptides that are produced.

Original languageEnglish (US)
Pages (from-to)443-473
Number of pages31
JournalAnnual Review of Immunology
Volume31
DOIs
StatePublished - Mar 1 2013

Keywords

  • Cross-presentation
  • MHC class I
  • MHC class II
  • Peptide
  • Proteolysis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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