Pathways of renal injury in systemic gram-negative sepsis

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the immune system. Recently, TLR4 and other co-effector molecules were identified on renal tubular and vascular cells. Furthermore, it was demonstrated that systemic endotoxin has direct access to renal sites where these receptors are expressed. Therefore, we review data in support of this novel pathway of renal injury in sepsis, whereby systemic endotoxin causes direct injury through interactions with local epithelial and endothelial TLR4.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Clinical Investigation
Volume38
Issue numberSUPPL.2
DOIs
StatePublished - Oct 2008

Fingerprint

Toll-Like Receptor 4
Endotoxins
Sepsis
Kidney
Wounds and Injuries
Immune system
Hemodynamics
Acute Kidney Injury
Blood Vessels
Immune System
Molecules

Keywords

  • Acute kidney injury
  • Acute renal failure
  • Endotoxin
  • TLR4
  • Toll-like receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

Cite this

Pathways of renal injury in systemic gram-negative sepsis. / Ashkar (El-Achkar), Tarek; Hosein, M.; Dagher, Pierre.

In: European Journal of Clinical Investigation, Vol. 38, No. SUPPL.2, 10.2008, p. 39-44.

Research output: Contribution to journalArticle

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