Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women

A randomized, controlled trial

Julia A. Schillinger, Patricia Kissinger, Helene Calvet, William L H Whittington, Ray L. Ransom, Maya R. Sternberg, Stuart M. Berman, Charlotte K. Kent, David H. Martin, M. Kim Oh, H. Hunter Handsfield, Gail Bolan, Lauri E. Markowitz, J. Fortenberry

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

Background: Repeated infection with Chlamydia trachomatis increases the risk for serious sequelae: pelvic inflammatory disease, ectopic pregnancy, infertility, and chronic pelvic pain. A substantial proportion of women treated for C trachomatis infection are reinfected by an untreated male sex partner in the first several months after treatment. Effective strategies to ensure partner treatment are needed. Goal: The goal of the study was to determine whether repeated infections with C trachomatis can be reduced by giving women doses of azithromycin to deliver to male sex partners. Study Design: A multicenter randomized controlled trial was conducted among 1787 women aged 14 to 34 years with uncomplicated C trachomatis genital infection diagnosed at family planning, adolescent, sexually transmitted disease, and primary care clinics or emergency or other hospital departments in five US cities. Women treated for infection were randomized to one of two groups: patient-delivered partner treatment (in which they were given a dose of azithromycin to deliver to each sex partner) or self-referral (in which they were asked to refer their sex partners for treatment). The main outcome measure was C trachomatis DNA detected by urine ligase chain reaction (LCR) or polymerase chain reaction (PCR) by 4 months after treatment. Results: The characteristics of study participants enrolled in each arm were similar except for a small difference in the age distribution. Risk of reinfection was 20% lower among women in the patient-delivered partner treatment arm (87/728; 12%) than among those in the self-referral arm (106/726; 15%); however, this difference was not statistically significant (odds ratio, 0.80; 95% confidence interval, 0.62-1.05; P = 0.102). Women in the patient-delivered partner treatment arm reported high compliance with the intervention (82%). Conclusion: Patient-delivered partner treatment for prevention of repeated C trachomatis infection among women is comparable to self-referral and may be an appropriate option for some patients.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalSexually Transmitted Diseases
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Chlamydia Infections
Azithromycin
Chlamydia trachomatis
Randomized Controlled Trials
Infection
Referral and Consultation
Therapeutics
Ligase Chain Reaction
Pelvic Inflammatory Disease
Pelvic Pain
Ectopic Pregnancy
Hospital Departments
Age Distribution
Family Planning Services
Sexually Transmitted Diseases
Chronic Pain
Infertility
Primary Health Care
Emergencies
Odds Ratio

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women : A randomized, controlled trial. / Schillinger, Julia A.; Kissinger, Patricia; Calvet, Helene; Whittington, William L H; Ransom, Ray L.; Sternberg, Maya R.; Berman, Stuart M.; Kent, Charlotte K.; Martin, David H.; Oh, M. Kim; Handsfield, H. Hunter; Bolan, Gail; Markowitz, Lauri E.; Fortenberry, J.

In: Sexually Transmitted Diseases, Vol. 30, No. 1, 01.01.2003, p. 49-56.

Research output: Contribution to journalArticle

Schillinger, JA, Kissinger, P, Calvet, H, Whittington, WLH, Ransom, RL, Sternberg, MR, Berman, SM, Kent, CK, Martin, DH, Oh, MK, Handsfield, HH, Bolan, G, Markowitz, LE & Fortenberry, J 2003, 'Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: A randomized, controlled trial', Sexually Transmitted Diseases, vol. 30, no. 1, pp. 49-56. https://doi.org/10.1097/00007435-200301000-00011
Schillinger, Julia A. ; Kissinger, Patricia ; Calvet, Helene ; Whittington, William L H ; Ransom, Ray L. ; Sternberg, Maya R. ; Berman, Stuart M. ; Kent, Charlotte K. ; Martin, David H. ; Oh, M. Kim ; Handsfield, H. Hunter ; Bolan, Gail ; Markowitz, Lauri E. ; Fortenberry, J. / Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women : A randomized, controlled trial. In: Sexually Transmitted Diseases. 2003 ; Vol. 30, No. 1. pp. 49-56.
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abstract = "Background: Repeated infection with Chlamydia trachomatis increases the risk for serious sequelae: pelvic inflammatory disease, ectopic pregnancy, infertility, and chronic pelvic pain. A substantial proportion of women treated for C trachomatis infection are reinfected by an untreated male sex partner in the first several months after treatment. Effective strategies to ensure partner treatment are needed. Goal: The goal of the study was to determine whether repeated infections with C trachomatis can be reduced by giving women doses of azithromycin to deliver to male sex partners. Study Design: A multicenter randomized controlled trial was conducted among 1787 women aged 14 to 34 years with uncomplicated C trachomatis genital infection diagnosed at family planning, adolescent, sexually transmitted disease, and primary care clinics or emergency or other hospital departments in five US cities. Women treated for infection were randomized to one of two groups: patient-delivered partner treatment (in which they were given a dose of azithromycin to deliver to each sex partner) or self-referral (in which they were asked to refer their sex partners for treatment). The main outcome measure was C trachomatis DNA detected by urine ligase chain reaction (LCR) or polymerase chain reaction (PCR) by 4 months after treatment. Results: The characteristics of study participants enrolled in each arm were similar except for a small difference in the age distribution. Risk of reinfection was 20{\%} lower among women in the patient-delivered partner treatment arm (87/728; 12{\%}) than among those in the self-referral arm (106/726; 15{\%}); however, this difference was not statistically significant (odds ratio, 0.80; 95{\%} confidence interval, 0.62-1.05; P = 0.102). Women in the patient-delivered partner treatment arm reported high compliance with the intervention (82{\%}). Conclusion: Patient-delivered partner treatment for prevention of repeated C trachomatis infection among women is comparable to self-referral and may be an appropriate option for some patients.",
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AU - Berman, Stuart M.

AU - Kent, Charlotte K.

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AU - Oh, M. Kim

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