Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia

Ellen M. Lavoie Smith, Lang Li, Chienwei Chiang, Karin Thomas, Raymond J. Hutchinson, Elizabeth M. Wells, Richard H. Ho, Jodi Skiles, Arindom Chakraborty, Celia M. Bridges, Jamie Renbarger

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Vincristine, a critical component of combination chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL), can lead to vincristine-induced peripheral neuropathy (VIPN). Longitudinal VIPN assessments were obtained over 12 months from newly diagnosed children with ALL (N=128) aged 1-18 years who received vincristine at one of four academic children's hospitals. VIPN assessments were obtained using the Total Neuropathy Score-Pediatric Vincristine (TNS

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalJournal of the Peripheral Nervous System
Volume20
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • acute lymphoblastic leukemia
  • children
  • patterns
  • severity
  • vincristine-induced peripheral neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Lavoie Smith, E. M., Li, L., Chiang, C., Thomas, K., Hutchinson, R. J., Wells, E. M., Ho, R. H., Skiles, J., Chakraborty, A., Bridges, C. M., & Renbarger, J. (2015). Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia. Journal of the Peripheral Nervous System, 20(1), 37-46. https://doi.org/10.1111/jns.12114