Patterns of ethanol and saccharin intake in P rats under limited-access conditions

K. L. Nowak, D. L. McKinzie, W. J. McBride, J. M. Murphy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Patterns of drinking and responding for ethanol (EtOH) and saccharin (SACC) were examined in the alcohol-preferring P rat using various limited- access paradigms. Adult female P rats (n = 10-20) were given 2-h access to EtOH (10-13% v/v) and SACC (0.0125% g/v) concurrently each day, or each solution individually on alternate days. Total 2-h SACC intake was significantly greater than EtOH under both concurrent (12 ± 2 vs. 7 ± 0.8 ml, p <0.05) and alternate-day access (18 ± 1.6 vs. 10 ± 0.5 ml) conditions. Under both conditions, however, EtOH intake (over 55% of the total) in the first 15 min was significantly greater than that of SACC (

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalAlcohol
Volume19
Issue number1
DOIs
StatePublished - Aug 1999
Externally publishedYes

Fingerprint

Saccharin
Rats
Ethanol
alcohol
paradigm
Drinking
Alcohols

Keywords

  • Alcohol
  • Drinking
  • Drug reward
  • Limited-access
  • Loss-of- control
  • Motivation
  • Operant responding
  • Saccharin

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Patterns of ethanol and saccharin intake in P rats under limited-access conditions. / Nowak, K. L.; McKinzie, D. L.; McBride, W. J.; Murphy, J. M.

In: Alcohol, Vol. 19, No. 1, 08.1999, p. 85-96.

Research output: Contribution to journalArticle

Nowak, K. L. ; McKinzie, D. L. ; McBride, W. J. ; Murphy, J. M. / Patterns of ethanol and saccharin intake in P rats under limited-access conditions. In: Alcohol. 1999 ; Vol. 19, No. 1. pp. 85-96.
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