PAX immunoreactivity in poorly differentiated small round cell tumors of childhood

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13 Scopus citations

Abstract

Paired box (PAX) gene antibodies have made it into the mainstream of tumor diagnosis in the recent years. We report the immunoreactivity expression patterns of three PAX genes (PAX2, PAX5 and PAX8) in poorly differentiated small round cell tumors of childhood for possible useful diagnostic applications. We collected and analyzed 123 cases of poorly differentiated small round cell tumors of childhood for their PAX immunoexpression patterns. The results indicated that PAX2 was strongly positive in all alveolar rhabdomyosarcomas and in two-thirds of the kidney clear cell sarcomas, and displayed variable expression in one-half of the embryonal rhabdomyosarcomas. PAX8 immunoexpression was noticed in five and three cases of alveolar rhabdomyosarcomas and embryonal rhabdomyosarcomas, respectively. About one-third of malignant rhabdoid tumors were PAX2-positive and PAX8-positive. All of the Ewing sarcoma and neuroblastoma cases stained negative with all three PAX stains.

Original languageEnglish (US)
Pages (from-to)244-252
Number of pages9
JournalFetal and Pediatric Pathology
Volume33
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • Clear cell sarcoma of kidney
  • Ewing sarcoma
  • Malignant rhabdoid tumor
  • Neuroblastoma
  • PAX2
  • PAX5
  • PAX8
  • Rhabdomyosarcoma
  • Small round cell tumor of childhood

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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