PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma

Chong Xian Pan, Michael S. Kinch, Peter A. Kiener, Solomon Langermann, Ginette Serrero, Le Sun, Joseph Corvera, Christopher J. Sweeney, Lang Li, Shaobo Zhang, Lee Ann Baldridge, Timothy D. Jones, Michael O. Koch, Thomas M. Ulbright, John N. Eble, Liang Cheng

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Purpose: PCDGF (PC cell-derived growth factor), also called progranulin, is a Mr 88,000 glycoprotein precursor of granulin. It is a novel growth factor that stimulates cell proliferation, confers epithelial tumorigenesis, and promotes tumor invasion. Here we investigate the potential of PCDGF as a therapeutic target for prostate cancer. Experimental Design: We studied the expression of PC-DGF in invasive prostate cancer, adjacent high-grade prostatic intraepithelial neoplasia (PIN), and benign prostate tissue from 99 human prostate specimens. The level of PC-DGF expression was correlated with various clinicopathological characteristics. Results: Normal prostate tissue did not express (53/99), or expressed low levels (46/99) of PCDGF. In the 46 normal prostate specimens that expressed PCDGF, most of them had less than 10% of cells expressing PCDGF. PCDGF expression could be detected in more than 50% of cells in all specimens of PIN and invasive prostate cancer. The expression of PCDGF in normal prostate tissue was much less intense and in a smaller fraction of cells than in PIN and invasive adenocarcinoma (P < 0.0001). There was no correlation of PCDGF expression with age, Gleason score, pathological stage, status of lymph node metastasis, extraprostatic extension, perineural invasion, surgical margins, and vascular invasion. Conclusions: Our data suggest that the induction of PCDGF expression occurs during the development of PIN. PCDGF may be a new molecular target for the treatment and prevention of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1333-1337
Number of pages5
JournalClinical Cancer Research
Volume10
Issue number4
DOIs
StatePublished - Feb 15 2004

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma'. Together they form a unique fingerprint.

  • Cite this

    Pan, C. X., Kinch, M. S., Kiener, P. A., Langermann, S., Serrero, G., Sun, L., Corvera, J., Sweeney, C. J., Li, L., Zhang, S., Baldridge, L. A., Jones, T. D., Koch, M. O., Ulbright, T. M., Eble, J. N., & Cheng, L. (2004). PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma. Clinical Cancer Research, 10(4), 1333-1337. https://doi.org/10.1158/1078-0432.CCR-1123-03