PE-1, a Novel ETS Oncogene Family Member, Localizes to Chromosome 1q21-q23

Michael Klemsz, Robert Hromas, Wendy Raskind, Edward Bruno, Ronald Hoffman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The v-ets\ oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalGenomics
Volume20
Issue number2
DOIs
StatePublished - Mar 15 1994

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Oncogenes
Chromosomes
Hairy Cell Leukemia
Cell Line
HL-60 Cells
Human Chromosomes
HLA-DR Antigens
Oligonucleotides
Cricetinae
In Situ Hybridization
Transcription Factors
Polymerase Chain Reaction
Peptides
Genes
ETS Motif

ASJC Scopus subject areas

  • Genetics

Cite this

PE-1, a Novel ETS Oncogene Family Member, Localizes to Chromosome 1q21-q23. / Klemsz, Michael; Hromas, Robert; Raskind, Wendy; Bruno, Edward; Hoffman, Ronald.

In: Genomics, Vol. 20, No. 2, 15.03.1994, p. 291-294.

Research output: Contribution to journalArticle

Klemsz, M, Hromas, R, Raskind, W, Bruno, E & Hoffman, R 1994, 'PE-1, a Novel ETS Oncogene Family Member, Localizes to Chromosome 1q21-q23', Genomics, vol. 20, no. 2, pp. 291-294. https://doi.org/10.1006/geno.1994.1169
Klemsz, Michael ; Hromas, Robert ; Raskind, Wendy ; Bruno, Edward ; Hoffman, Ronald. / PE-1, a Novel ETS Oncogene Family Member, Localizes to Chromosome 1q21-q23. In: Genomics. 1994 ; Vol. 20, No. 2. pp. 291-294.
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