Pe-1, a novel ets oncogene family member, localizes to chromosome 1q21-q23

Michael Klemsz, Robert Hromas, Wendy Raskind, Edward Bruno, Ronald Hoffman

Research output: Contribution to journalArticle

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Abstract

The v-ets\ oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalGenomics
Volume20
Issue number2
DOIs
StatePublished - Mar 15 1994

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ASJC Scopus subject areas

  • Genetics

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