Peak bone mineral density at the hip is linked to chromosomes 14q and 15q

Munro Peacock, Daniel L. Koller, Siu Hui, C. Conrad Johnston, Tatiana Foroud, Michael Econs

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A major determinant of osteoporotic hip fracture is peak hip BMD which is a highly heritable trait. Caucasian American women have lower BMD and higher hip fracture rates than African American women. This study examines linkage of hip BMD in 570 Caucasian sister pairs and 204 African American sister pairs. It compares the results with our published study in a smaller overlapping sample of Caucasian sisters. Hip BMD was measured at neck, trochanter, Ward's, shaft, and total hip. Principal component analysis provided a novel BMD phenotype comprising neck and trochanter, common sites of fracture, and Ward's, site of lowest BMD. A 9 cM genome scan was performed for these phenotypes. Significant linkage was found at chromosomes 14q and 15q. At 14q, the 774 African American and Caucasian sister pairs together yielded the highest LOD score for trochanter (3.5) and at 15q the highest LOD score for femoral neck (4.3). This linkage study in Caucasian and African American healthy premenopausal sisters demonstrates that chromosomes 14q and 15q harbor genes that affect peak bone mass at the hip in women. Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes.

Original languageEnglish
Pages (from-to)489-496
Number of pages8
JournalOsteoporosis International
Volume15
Issue number6
StatePublished - Jun 2004

Fingerprint

Bone Density
Hip
Chromosomes
Siblings
African Americans
Femur
Phenotype
Hip Fractures
Neck
Genetic Pleiotropy
Osteoporotic Fractures
Femur Neck
Principal Component Analysis
Genome
Bone and Bones
Genes

Keywords

  • African American
  • Bone mineral density
  • Caucasian
  • Femoral neck BMD
  • Genes
  • Genome scan
  • Hip fracture
  • Osteoporosis
  • Principal component analysis
  • QTL
  • Total hip BMD
  • Trochanter BMD

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peak bone mineral density at the hip is linked to chromosomes 14q and 15q. / Peacock, Munro; Koller, Daniel L.; Hui, Siu; Johnston, C. Conrad; Foroud, Tatiana; Econs, Michael.

In: Osteoporosis International, Vol. 15, No. 6, 06.2004, p. 489-496.

Research output: Contribution to journalArticle

@article{68624091db454bcd8155d10207e3251d,
title = "Peak bone mineral density at the hip is linked to chromosomes 14q and 15q",
abstract = "A major determinant of osteoporotic hip fracture is peak hip BMD which is a highly heritable trait. Caucasian American women have lower BMD and higher hip fracture rates than African American women. This study examines linkage of hip BMD in 570 Caucasian sister pairs and 204 African American sister pairs. It compares the results with our published study in a smaller overlapping sample of Caucasian sisters. Hip BMD was measured at neck, trochanter, Ward's, shaft, and total hip. Principal component analysis provided a novel BMD phenotype comprising neck and trochanter, common sites of fracture, and Ward's, site of lowest BMD. A 9 cM genome scan was performed for these phenotypes. Significant linkage was found at chromosomes 14q and 15q. At 14q, the 774 African American and Caucasian sister pairs together yielded the highest LOD score for trochanter (3.5) and at 15q the highest LOD score for femoral neck (4.3). This linkage study in Caucasian and African American healthy premenopausal sisters demonstrates that chromosomes 14q and 15q harbor genes that affect peak bone mass at the hip in women. Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes.",
keywords = "African American, Bone mineral density, Caucasian, Femoral neck BMD, Genes, Genome scan, Hip fracture, Osteoporosis, Principal component analysis, QTL, Total hip BMD, Trochanter BMD",
author = "Munro Peacock and Koller, {Daniel L.} and Siu Hui and Johnston, {C. Conrad} and Tatiana Foroud and Michael Econs",
year = "2004",
month = "6",
language = "English",
volume = "15",
pages = "489--496",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "6",

}

TY - JOUR

T1 - Peak bone mineral density at the hip is linked to chromosomes 14q and 15q

AU - Peacock, Munro

AU - Koller, Daniel L.

AU - Hui, Siu

AU - Johnston, C. Conrad

AU - Foroud, Tatiana

AU - Econs, Michael

PY - 2004/6

Y1 - 2004/6

N2 - A major determinant of osteoporotic hip fracture is peak hip BMD which is a highly heritable trait. Caucasian American women have lower BMD and higher hip fracture rates than African American women. This study examines linkage of hip BMD in 570 Caucasian sister pairs and 204 African American sister pairs. It compares the results with our published study in a smaller overlapping sample of Caucasian sisters. Hip BMD was measured at neck, trochanter, Ward's, shaft, and total hip. Principal component analysis provided a novel BMD phenotype comprising neck and trochanter, common sites of fracture, and Ward's, site of lowest BMD. A 9 cM genome scan was performed for these phenotypes. Significant linkage was found at chromosomes 14q and 15q. At 14q, the 774 African American and Caucasian sister pairs together yielded the highest LOD score for trochanter (3.5) and at 15q the highest LOD score for femoral neck (4.3). This linkage study in Caucasian and African American healthy premenopausal sisters demonstrates that chromosomes 14q and 15q harbor genes that affect peak bone mass at the hip in women. Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes.

AB - A major determinant of osteoporotic hip fracture is peak hip BMD which is a highly heritable trait. Caucasian American women have lower BMD and higher hip fracture rates than African American women. This study examines linkage of hip BMD in 570 Caucasian sister pairs and 204 African American sister pairs. It compares the results with our published study in a smaller overlapping sample of Caucasian sisters. Hip BMD was measured at neck, trochanter, Ward's, shaft, and total hip. Principal component analysis provided a novel BMD phenotype comprising neck and trochanter, common sites of fracture, and Ward's, site of lowest BMD. A 9 cM genome scan was performed for these phenotypes. Significant linkage was found at chromosomes 14q and 15q. At 14q, the 774 African American and Caucasian sister pairs together yielded the highest LOD score for trochanter (3.5) and at 15q the highest LOD score for femoral neck (4.3). This linkage study in Caucasian and African American healthy premenopausal sisters demonstrates that chromosomes 14q and 15q harbor genes that affect peak bone mass at the hip in women. Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes.

KW - African American

KW - Bone mineral density

KW - Caucasian

KW - Femoral neck BMD

KW - Genes

KW - Genome scan

KW - Hip fracture

KW - Osteoporosis

KW - Principal component analysis

KW - QTL

KW - Total hip BMD

KW - Trochanter BMD

UR - http://www.scopus.com/inward/record.url?scp=3042544055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042544055&partnerID=8YFLogxK

M3 - Article

C2 - 15205721

AN - SCOPUS:3042544055

VL - 15

SP - 489

EP - 496

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 6

ER -