Pearls and pitfalls in the diagnosis and management of neuromuscular junction disorders

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Myasthenia gravis (MG) is a common autoimmune disorder characterized by the presence of pathogenic antibodies directed against the acetylcholine receptor. Patients present with variable degrees and distribution of fluctuating weakness, at times life-threatening. Clinical manifestations, establishment of diagnosis, the natural history of MG, and therapeutic options are herein reviewed with an emphasis on pearls and pitfalls of clinical relevance. Far less common is Lambert-Eaton syndrome (the myasthenic syndrome), another autoimmune disorder due to the presence of antibodies directed against the PQ-type voltage-gated calcium channels. Clinical features and treatment issues of these and other disorders of neuromuscular transmission are reviewed.

Original languageEnglish
Pages (from-to)425-440
Number of pages16
JournalSeminars in Neurology
Volume21
Issue number4
DOIs
StatePublished - 2001

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Neuromuscular Junction Diseases
Myasthenia Gravis
Lambert-Eaton Myasthenic Syndrome
Antibodies
Cholinergic Receptors
Calcium Channels
Therapeutics

Keywords

  • Botulism
  • Immunotherapy of neuromuscular disease
  • Lambert-Eaton syndrome
  • Myasthenia gravis
  • Plasma exchange
  • Tick paralysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pearls and pitfalls in the diagnosis and management of neuromuscular junction disorders. / Pascuzzi, Robert.

In: Seminars in Neurology, Vol. 21, No. 4, 2001, p. 425-440.

Research output: Contribution to journalArticle

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