Pearls and pitfalls in the diagnosis and management of neuromuscular junction disorders

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Myasthenia gravis (MG) is a common autoimmune disorder characterized by the presence of pathogenic antibodies directed against the acetylcholine receptor. Patients present with variable degrees and distribution of fluctuating weakness, at times life-threatening. Clinical manifestations, establishment of diagnosis, the natural history of MG, and therapeutic options are herein reviewed with an emphasis on pearls and pitfalls of clinical relevance. Far less common is Lambert-Eaton syndrome (the myasthenic syndrome), another autoimmune disorder due to the presence of antibodies directed against the PQ-type voltage-gated calcium channels. Clinical features and treatment issues of these and other disorders of neuromuscular transmission are reviewed.

Original languageEnglish (US)
Pages (from-to)425-440
Number of pages16
JournalSeminars in neurology
Volume21
Issue number4
DOIs
StatePublished - Dec 1 2001

Keywords

  • Botulism
  • Immunotherapy of neuromuscular disease
  • Lambert-Eaton syndrome
  • Myasthenia gravis
  • Plasma exchange
  • Tick paralysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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