Pediatric assent for a study of antiretroviral therapy dosing for children in Western Kenya: A case study in international research collaboration

Rachel C. Vreeman, Winstone M. Nyandiko, Eric M. Meslin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Multinational collaborators in health research face particular ethical challenges when conducting studies involving vulnerable populations such as children. We use an example from our first attempt to implement pediatric assent in the context of a longstanding research and clinical partnership between Kenyan and American medical schools to highlight the ethical and procedural issues related to pediatric assent that must be considered for multinational, pediatric studies. We consider relevant domestic, professional, and international guidelines for assent in pediatric research subjects, and we discuss the particular ethical challenges related to pediatric assent in the Kenyan context. Finally, we propose a way forward for approaching pediatric assent within our collaborative research program in Kenya that may apply to other multinational research partnerships.

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalJournal of Empirical Research on Human Research Ethics
Volume4
Issue number1
DOIs
StatePublished - Jul 23 2009

Keywords

  • Assent
  • Cchildren
  • Pediatric assent

ASJC Scopus subject areas

  • Education
  • Communication
  • Social Psychology
  • Law

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