Pediatric Epilepsy Surgery at the University of Alberta

1988-2000

D. Barry Sinclair, Keith E. Aronyk, Thomas J. Snyder, B. Matt Wheatley, John D.S. McKean, Ravi Bhargava, M. Hoskinson, Chunhai Hao, William F. Colmers, Marjorie Berg, William Mak

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Epilepsy surgery is considered a treatment option for patients with intractable seizures. Relatively few studies of efficacy, safety, and long-term outcome are available for the pediatric age group. This study describes a 12-year experience with pediatric epilepsy surgery at the University of Alberta. Records of pediatric epilepsy surgery patients admitted to the Comprehensive Epilepsy Program at the University of Alberta between 1988 and 2000 were reviewed. All patients received preoperative and postoperative clinical evaluation, seizure charts, testing of drug levels, electroencephalogram, computed tomography/magnetic resonance imaging, neuropsychologic testing, and long-term video electroencephalogram monitoring. The patients were reassessed after surgery at 6 weeks, 6 months, and 1 year and then yearly. The duration of follow-up was 1 year to 12 years. Forty-two patients underwent temporal lobectomies; 35, extratemporal resection. The age at surgery ranged from 6 months to 16 years. Thirty-two (76%) of temporal lobe patients became seizure-free (Engel Class I) vs 24 (68%) for the extratemporal group (Engel Class I). One patient (2%) in the temporal group had an Engel Class II outcome and one patient (3%) in the extratemporal group had the same Engel Class II outcome. Three patients (4%) manifested postoperative complications, and there were no deaths. Patients reported improvement in cognitive abilities, behavior, and quality of life after the surgery. Epilepsy surgery in children is effective and safe. Many children are seizure-free after the operation and remain so, although the results of temporal lobectomy are better than for extratemporal resections. There are few complications, and children often have an improved quality of life.

Original languageEnglish (US)
Pages (from-to)302-311
Number of pages10
JournalPediatric Neurology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Alberta
Epilepsy
Pediatrics
Seizures
Electroencephalography
Quality of Life
Temporal Lobe
Age Groups
Tomography
Magnetic Resonance Imaging
Safety

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Sinclair, D. B., Aronyk, K. E., Snyder, T. J., Wheatley, B. M., McKean, J. D. S., Bhargava, R., ... Mak, W. (2003). Pediatric Epilepsy Surgery at the University of Alberta: 1988-2000. Pediatric Neurology, 29(4), 302-311. https://doi.org/10.1016/S0887-8994(03)00307-2

Pediatric Epilepsy Surgery at the University of Alberta : 1988-2000. / Sinclair, D. Barry; Aronyk, Keith E.; Snyder, Thomas J.; Wheatley, B. Matt; McKean, John D.S.; Bhargava, Ravi; Hoskinson, M.; Hao, Chunhai; Colmers, William F.; Berg, Marjorie; Mak, William.

In: Pediatric Neurology, Vol. 29, No. 4, 01.01.2003, p. 302-311.

Research output: Contribution to journalArticle

Sinclair, DB, Aronyk, KE, Snyder, TJ, Wheatley, BM, McKean, JDS, Bhargava, R, Hoskinson, M, Hao, C, Colmers, WF, Berg, M & Mak, W 2003, 'Pediatric Epilepsy Surgery at the University of Alberta: 1988-2000', Pediatric Neurology, vol. 29, no. 4, pp. 302-311. https://doi.org/10.1016/S0887-8994(03)00307-2
Sinclair DB, Aronyk KE, Snyder TJ, Wheatley BM, McKean JDS, Bhargava R et al. Pediatric Epilepsy Surgery at the University of Alberta: 1988-2000. Pediatric Neurology. 2003 Jan 1;29(4):302-311. https://doi.org/10.1016/S0887-8994(03)00307-2
Sinclair, D. Barry ; Aronyk, Keith E. ; Snyder, Thomas J. ; Wheatley, B. Matt ; McKean, John D.S. ; Bhargava, Ravi ; Hoskinson, M. ; Hao, Chunhai ; Colmers, William F. ; Berg, Marjorie ; Mak, William. / Pediatric Epilepsy Surgery at the University of Alberta : 1988-2000. In: Pediatric Neurology. 2003 ; Vol. 29, No. 4. pp. 302-311.
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