Pediatric Intestinal Foregut and Small Bowel Solid Tumors: A Review of 105 Cases

Ying Zhuge, Michael C. Cheung, Relin Yang, Dalal Eldick, Leonidas Koniaris, Juan E. Sola

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: The outcomes of pediatric intestinal foregut and small bowel solid tumors have never been studied on a population scale. Materials and Methods: The Surveillance, Epidemiology, and End Results database (1973-2005) was queried for all patients under 20 y of age. Results: A total of 105 cases of pediatric intestinal foregut and small bowel solid tumors were identified. Tumors occurred in the esophagus (8.6%), stomach (61%), and small bowel (30.5%). The most common histologies include sarcoma (43.8%), which consisted mostly of gastrointestinal stromal tumors (GIST), carcinoma (41.0%), which consisted mostly of adenocarcinomas, and neuroendocrine tumors (NET) (10.5%). Most tumors were poorly differentiated and presented with advanced disease. The overall median survival time was 207 mo. Gastric solid tumors had significantly worse 5- and 10-y survival compared with their small bowel counterparts, though this difference disappeared in those who received surgical resection. Patients with carcinoma had significantly worse survival compared with those with sarcoma or NET, regardless of site and surgical intervention. Univariate analysis identified race, differentiation, stage, and surgery as significant predictors of survival. Multivariate analysis revealed that African American race, advanced stage of disease, carcinoma histology, and failure to undergo surgical extirpation were all independent predictors of worse outcome. In patients with carcinoma, failure to undergo radiotherapy was also a predictor of worse outcome. Conclusion: Surgery is associated with a significantly improved survival for pediatric patients with solid tumors of the intestinal foregut and small bowel. Radiotherapy appears to be an important adjuvant therapy for patients with carcinoma.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalJournal of Surgical Research
Volume156
Issue number1
DOIs
StatePublished - Sep 2009
Externally publishedYes

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Pediatrics
Carcinoma
Survival
Neoplasms
Neuroendocrine Tumors
Sarcoma
Stomach
Histology
Radiotherapy
Gastrointestinal Stromal Tumors
African Americans
Esophagus
Epidemiology
Adenocarcinoma
Multivariate Analysis
Databases
Population
Therapeutics

Keywords

  • foregut
  • outcomes
  • pediatrics
  • SEER
  • small bowel
  • solid tumors

ASJC Scopus subject areas

  • Surgery

Cite this

Pediatric Intestinal Foregut and Small Bowel Solid Tumors : A Review of 105 Cases. / Zhuge, Ying; Cheung, Michael C.; Yang, Relin; Eldick, Dalal; Koniaris, Leonidas; Sola, Juan E.

In: Journal of Surgical Research, Vol. 156, No. 1, 09.2009, p. 95-102.

Research output: Contribution to journalArticle

Zhuge, Ying ; Cheung, Michael C. ; Yang, Relin ; Eldick, Dalal ; Koniaris, Leonidas ; Sola, Juan E. / Pediatric Intestinal Foregut and Small Bowel Solid Tumors : A Review of 105 Cases. In: Journal of Surgical Research. 2009 ; Vol. 156, No. 1. pp. 95-102.
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