Pediatric nonalcoholic fatty liver disease

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the pediatric population. Increased recognition of this form of liver disease parallels the dramatic rise in childhood and adolescent obesity over the past 2 decades. Like adults, most children with NAFLD are obese, and comorbidities include insulin resistance, hypertension, and dyslipidemia. Unfortunately, pediatric NAFLD is not always a benign condition, with some children progressing to hepatic fibrosis and even cirrhosis in severe cases. The etiology of nonalcoholic steatohepatitis is not yet fully understood; however, hepatic steatosis in the context of insulin resistance and increased oxidative stress may lead to progressive disease. Although physical examination, laboratory evaluation, and radiographic findings provide clues to the potential presence of fatty liver disease, liver biopsy remains the gold standard for diagnosis. Lifestyle modification, including slow and steady weight loss, improved dietary habits, and increased daily, aerobic physical activity, remains the first-line approach in treating pediatric fatty liver disease. Antioxidant pharmacologic therapy such as use of vitamin E has shown some benefit in patients with biopsy-proven steatohepatitis. Nutrition plays an essential role not only in the development of fatty liver disease but also potentially in the treatment and prevention of progression to more severe disease.

Original languageEnglish
Pages (from-to)448-458
Number of pages11
JournalNutrition in Clinical Practice
Volume28
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Liver Diseases
Fatty Liver
Pediatrics
Pediatric Obesity
Insulin Resistance
Liver
Fibrosis
Biopsy
Feeding Behavior
Dyslipidemias
Vitamin E
Physical Examination
Life Style
Comorbidity
Weight Loss
Oxidative Stress
Chronic Disease
Antioxidants
Non-alcoholic Fatty Liver Disease
Exercise

Keywords

  • liver diseases
  • non-alcoholic fatty liver disease
  • obesity fatty liver
  • pediatrics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Pediatric nonalcoholic fatty liver disease. / Bozic, Molly A.; Subbarao, Girish; Molleston, Jean.

In: Nutrition in Clinical Practice, Vol. 28, No. 4, 08.2013, p. 448-458.

Research output: Contribution to journalArticle

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