Pediatric pharyngeal IgD-positive monoclonal plasmacytoid and plasma cell neoplasm

Shanxiang Zhang, Catherine Long

Research output: Contribution to journalArticle

Abstract

Pediatric neoplasm with monoclonal proliferation of lymphoplasmacytoid lymphocytes and plasma cells is exceedingly rare and has essentially never been reported in immunocompetent children. Here, we report a previously healthy 13-year-old girl with a pharyngeal mass and enlarged cervical lymph nodes. The pharyngeal mass was composed of CD138+, CD79a+, MUM-1+, IgD+, CD20-, PAX-5-, CD43-, λ-restricted monoclonal plasmacytoid, and plasma cells. Scattered CD20+, PAX-5+ B cells were present in the background. The patient was treated as localized non-Hodgkin lymphoma (stage II) with cyclophosphamide, doxorubicin, vincristine, and prednisone and is in complete remission at 17 months from the last chemotherapy.

Original languageEnglish (US)
Pages (from-to)623-626
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number8
DOIs
StatePublished - Oct 23 2015

Keywords

  • Immunocompetent children
  • Immunoglobulin D positive
  • Lymphoplasmacytoid lymphocytes
  • Neoplasm
  • Plasma cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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