Pediatric neoplasm with monoclonal proliferation of lymphoplasmacytoid lymphocytes and plasma cells is exceedingly rare and has essentially never been reported in immunocompetent children. Here, we report a previously healthy 13-year-old girl with a pharyngeal mass and enlarged cervical lymph nodes. The pharyngeal mass was composed of CD138+, CD79a+, MUM-1+, IgD+, CD20-, PAX-5-, CD43-, λ-restricted monoclonal plasmacytoid, and plasma cells. Scattered CD20+, PAX-5+ B cells were present in the background. The patient was treated as localized non-Hodgkin lymphoma (stage II) with cyclophosphamide, doxorubicin, vincristine, and prednisone and is in complete remission at 17 months from the last chemotherapy.
- Immunocompetent children
- Immunoglobulin D positive
- Lymphoplasmacytoid lymphocytes
- Plasma cells
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health