PedsQL eosinophilic esophagitis module: Feasibility, reliability, and validity

James P. Franciosi, Kevin A. Hommel, Cristiane B. Bendo, Eileen C. King, Margaret H. Collins, Michael D. Eby, Keith Marsolo, J. Pablo Abonia, Karl F. Von Tiehl, Philip E. Putnam, Alexandria J. Greenler, Allison B. Greenberg, Ronald A. Bryson, Carla M. Davis, Anthony P. Olive, Sandeep K. Gupta, Elizabeth A. Erwin, Mary D. Klinnert, Jonathan M. Spergel, Jolanda M. DenhamGlenn T. Furuta, Marc E. Rothenberg, James W. Varni

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

OBJECTIVE: Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory condition with a paucity of information on health-related quality of life (HRQOL). The objective of the study was to report on the measurement properties of the PedsQL EoE Module. METHODS: The PedsQL EoE Module was completed in a multisite study by 196 pediatric patients with EoE and 262 parents of patients with EoE. RESULTS: The PedsQL EoE Module scales evidenced excellent feasibility (0.6%-3.1% missing), excellent group comparison reliability across total scale scores (patient α 0.93; parent proxy α 0.94), good reliability for the 7 individual scales (patient α 0.75-0.87; parent proxy α 0.81-0.92), excellent test-retest reliability (patient intraclass correlation coefficient 0.88; parent intraclass correlation coefficient 0.82), demonstrated no floor effects and low ceiling effects, and demonstrated a high percentage of scaling success for most scales. Intercorrelations with the PedsQL Generic Core Scales were in the medium (0.30) to large (0.50) range. PedsQL EoE Module scores were worse among patients with active histologic disease (≥5 eos/hpf) compared with those in remission (patient self-report: 63.3 vs 69.9 [P<0.05]; parent proxy report: 65.1 vs 72.3 [P<0.01]), and those treated with dietary restrictions compared with those with no restrictions (patient self-report: 61.6 vs 74.3 [P<0.01]; parent proxy report: 65.5 vs 74.7 [P<0.01]). CONCLUSIONS: The results demonstrate excellent measurement properties of the PedsQL EoE Module. Patients with active histologic disease and those treated with dietary restrictions demonstrated worse PedsQL scores. The PedsQL EoE Module may be used in the evaluation of pediatric EoE disease-specific HRQOL in clinical research and practice.

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalJournal of pediatric gastroenterology and nutrition
Volume57
Issue number1
DOIs
StatePublished - Jul 1 2013

Keywords

  • Children
  • Eosinophilic esophagitis
  • Health-related quality of life
  • Patient-reported outcomes
  • Pediatrics
  • PedsQL

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

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    Franciosi, J. P., Hommel, K. A., Bendo, C. B., King, E. C., Collins, M. H., Eby, M. D., Marsolo, K., Abonia, J. P., Von Tiehl, K. F., Putnam, P. E., Greenler, A. J., Greenberg, A. B., Bryson, R. A., Davis, C. M., Olive, A. P., Gupta, S. K., Erwin, E. A., Klinnert, M. D., Spergel, J. M., ... Varni, J. W. (2013). PedsQL eosinophilic esophagitis module: Feasibility, reliability, and validity. Journal of pediatric gastroenterology and nutrition, 57(1), 57-66. https://doi.org/10.1097/MPG.0b013e31828f1fd2