Interferon alpha is the foundation of therapy for patients with chronic hepatitis C infection. However, the sustained virologic response (SVR) rates for conventional interferons alone given 3 times per week are unsatisfactory but dramatically improve with the addition of ribavirin. Pegylated interferon is formed by conjugation of polyethylene glycol (PEG) to conventional interferon. The attachment of PEG to the parent protein results in enhanced pharmacokinetic and pharmacodynamic profiles of interferon and yields results that are superior to conventional interferon in the treatment of chronic hepatitis C. Moreover, the combination of ribavirin and pegylated interferon has improved sustained response rates and is now the gold standard for treatment of hepatitis C.
|Original language||English (US)|
|Number of pages||5|
|Journal||Clinical Perspectives in Gastroenterology|
|State||Published - Sep 1 2002|
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