Pegylated interferon

Amar G. Pinto, Paul Y. Kwo

Research output: Contribution to journalArticle

Abstract

Interferon alpha is the foundation of therapy for patients with chronic hepatitis C infection. However, the sustained virologic response (SVR) rates for conventional interferons alone given 3 times per week are unsatisfactory but dramatically improve with the addition of ribavirin. Pegylated interferon is formed by conjugation of polyethylene glycol (PEG) to conventional interferon. The attachment of PEG to the parent protein results in enhanced pharmacokinetic and pharmacodynamic profiles of interferon and yields results that are superior to conventional interferon in the treatment of chronic hepatitis C. Moreover, the combination of ribavirin and pegylated interferon has improved sustained response rates and is now the gold standard for treatment of hepatitis C.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalClinical Perspectives in Gastroenterology
Volume5
Issue number5
StatePublished - Sep 2002
Externally publishedYes

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Interferons
Ribavirin
Chronic Hepatitis C
Hepatitis C
Interferon-alpha
Therapeutics
Pharmacokinetics
Infection
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pinto, A. G., & Kwo, P. Y. (2002). Pegylated interferon. Clinical Perspectives in Gastroenterology, 5(5), 292-296.

Pegylated interferon. / Pinto, Amar G.; Kwo, Paul Y.

In: Clinical Perspectives in Gastroenterology, Vol. 5, No. 5, 09.2002, p. 292-296.

Research output: Contribution to journalArticle

Pinto, AG & Kwo, PY 2002, 'Pegylated interferon', Clinical Perspectives in Gastroenterology, vol. 5, no. 5, pp. 292-296.
Pinto AG, Kwo PY. Pegylated interferon. Clinical Perspectives in Gastroenterology. 2002 Sep;5(5):292-296.
Pinto, Amar G. ; Kwo, Paul Y. / Pegylated interferon. In: Clinical Perspectives in Gastroenterology. 2002 ; Vol. 5, No. 5. pp. 292-296.
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