Pemetrexed (Alimta®)

Improving outcomes in malignant pleural mesothelioma

Leanne S. Budde, Nasser Hanna

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

During the past four decades, chemotherapy has failed to demonstrate a consistent clinical benefit for patients with unresectable or recurrent malignant pleural mesothelloma (MPM). Consequently, there has been no standard chemotherapy nor US Food and Drug Administration (FDA)-approved drug for patients with this disease. The Introduction of pemetrexed (Alimta®, Eli Lilly), a multitargeted antifolate agent, has improved the outlook for patients with mesothelioma by demonstrating a positive impact on quality of life and by prolonging survival. Pemetrexed is the first FDA-approved drug for the treatment of MPM. The combination of cisplatin plus pemetrexed is now the standard of care for the treatment of the disease. Furthermore, supplementation with vitamin B12 and folate has vastly improved the toxicity profile of pemetrexed. This article summarizes historical chemotherapy trials in MPM; discusses key features of clinical trial design for MPM; summarizes the results of a landmark Phase III trial of pemetrexed and cisplatin in MPM; discusses the relative contributions of pemetrexed and cisplatin to the regimen; explains the importance of vitamin supplementation of pemetrexed; and provides direction for future clinical trials in this disease.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalExpert Review of Anticancer Therapy
Volume4
Issue number3
StatePublished - Jun 2004

Fingerprint

Pemetrexed
Cisplatin
United States Food and Drug Administration
Drug Therapy
Clinical Trials
Folic Acid Antagonists
Malignant Mesothelioma
Mesothelioma
Vitamin B 12
Standard of Care
Folic Acid
Vitamins
Pharmaceutical Preparations
Quality of Life

Keywords

  • Antifolate
  • Mesothelioma
  • Pemetrexed

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

Cite this

Pemetrexed (Alimta®) : Improving outcomes in malignant pleural mesothelioma. / Budde, Leanne S.; Hanna, Nasser.

In: Expert Review of Anticancer Therapy, Vol. 4, No. 3, 06.2004, p. 361-368.

Research output: Contribution to journalArticle

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