Peptidoglycan recognition in innate immunity

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The innate immune system recognizes micro-organisms through a series of pattern recognition receptors that are highly conserved in evolution. Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, is not present in eukaryotes, and is an excellent target for the innate immune system. Indeed, higher eukaryotes, including mammals, have several PGN recognition molecules, including CD14, Toll-like receptor 2 (TLR2), nucleotide oligomerization domain (Nod)-containing proteins, a family of peptidoglycan recognition proteins (PGRPs), and PGN-lytic enzymes (lysozyme and amidase). These molecules induce host responses to micro-organisms, degrade PGN, or have direct antimicrobial effects.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalJournal of Endotoxin Research
Volume11
Issue number5
DOIs
StatePublished - Nov 14 2005

Keywords

  • CD14
  • Innate immunity
  • Nod
  • Peptidoglycan
  • Peptidoglycan recognition proteins
  • Toll-like receptors

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Toxicology

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