Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB

Ming Fei Lang, Armin Schneider, Carola Krüger, Roland Schmid, Roman Dziarski, Markus Schwaninger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cerebral ischemia triggers inflammation and apoptosis, and the transcription factor NF-κB is a key regulator of both events. Here, we report on the induction of the peptidoglycan recognition protein-S (PGRP-S) in a mouse model of cerebral ischemia. Upregulation was reduced if the NF-κB subunit RelA was conditionally deleted in the brain. Regulation of PGRP-S transcription by RelA was confirmed in vitro. Cotransfection of a RelA expression plasmid stimulated the expression of a PGRP-S luciferase fusion gene. Mutation of two NF-κB response elements in the PGRP-S promoter disrupted stimulation by RelA. To investigate the function of PGRP-S in cerebral ischemia, we subjected PGRP-S-/- mice to cerebral ischemia. However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalNeuroscience Letters
Volume430
Issue number2
DOIs
StatePublished - Jan 10 2008

Fingerprint

Protein S
Brain Ischemia
peptidoglycan recognition protein
Gene Fusion
Response Elements
Luciferases
Plasmids
Transcription Factors
Up-Regulation
Ischemia
Apoptosis
Inflammation
Mutation
Brain

Keywords

  • Cerebral ischemia
  • NF-κB
  • PGRP-S
  • RelA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lang, M. F., Schneider, A., Krüger, C., Schmid, R., Dziarski, R., & Schwaninger, M. (2008). Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB. Neuroscience Letters, 430(2), 138-141. https://doi.org/10.1016/j.neulet.2007.10.027

Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB. / Lang, Ming Fei; Schneider, Armin; Krüger, Carola; Schmid, Roland; Dziarski, Roman; Schwaninger, Markus.

In: Neuroscience Letters, Vol. 430, No. 2, 10.01.2008, p. 138-141.

Research output: Contribution to journalArticle

Lang, MF, Schneider, A, Krüger, C, Schmid, R, Dziarski, R & Schwaninger, M 2008, 'Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB', Neuroscience Letters, vol. 430, no. 2, pp. 138-141. https://doi.org/10.1016/j.neulet.2007.10.027
Lang, Ming Fei ; Schneider, Armin ; Krüger, Carola ; Schmid, Roland ; Dziarski, Roman ; Schwaninger, Markus. / Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB. In: Neuroscience Letters. 2008 ; Vol. 430, No. 2. pp. 138-141.
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