Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB

Ming Fei Lang, Armin Schneider, Carola Krüger, Roland Schmid, Roman Dziarski, Markus Schwaninger

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5 Scopus citations

Abstract

Cerebral ischemia triggers inflammation and apoptosis, and the transcription factor NF-κB is a key regulator of both events. Here, we report on the induction of the peptidoglycan recognition protein-S (PGRP-S) in a mouse model of cerebral ischemia. Upregulation was reduced if the NF-κB subunit RelA was conditionally deleted in the brain. Regulation of PGRP-S transcription by RelA was confirmed in vitro. Cotransfection of a RelA expression plasmid stimulated the expression of a PGRP-S luciferase fusion gene. Mutation of two NF-κB response elements in the PGRP-S promoter disrupted stimulation by RelA. To investigate the function of PGRP-S in cerebral ischemia, we subjected PGRP-S-/- mice to cerebral ischemia. However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalNeuroscience Letters
Volume430
Issue number2
DOIs
StatePublished - Jan 10 2008

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Keywords

  • Cerebral ischemia
  • NF-κB
  • PGRP-S
  • RelA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lang, M. F., Schneider, A., Krüger, C., Schmid, R., Dziarski, R., & Schwaninger, M. (2008). Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB. Neuroscience Letters, 430(2), 138-141. https://doi.org/10.1016/j.neulet.2007.10.027