Peptidoglycan Recognition Proteins-Maintaining Immune Homeostasis and Normal Development

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Peptidoglycan recognition proteins (PGRPs) are innate immune molecules with a diverse array of functions. In this issue of Cell Host & Microbe, Maillet and colleagues demonstrate that a Drosophila PGRP, PGRP-LF, functions as a negative regulator of the Drosophila immune deficiency (IMD) pathway, an innate immune signaling mechanism responsive to Gram-negative bacteria. PGRP-LF deficiency results in unregulated immune signaling, causing excessive antimicrobial peptide synthesis and, surprisingly, developmental defects.

Original languageEnglish
Pages (from-to)273-274
Number of pages2
JournalCell Host and Microbe
Volume3
Issue number5
DOIs
StatePublished - May 15 2008

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Homeostasis
Drosophila
Protein Deficiency
Gram-Negative Bacteria
Peptides
peptidoglycan recognition protein

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Peptidoglycan Recognition Proteins-Maintaining Immune Homeostasis and Normal Development. / Gupta, Dipika.

In: Cell Host and Microbe, Vol. 3, No. 5, 15.05.2008, p. 273-274.

Research output: Contribution to journalArticle

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