Peptidoglycan Recognition Proteins-Maintaining Immune Homeostasis and Normal Development

Research output: Contribution to journalShort survey

6 Scopus citations


Peptidoglycan recognition proteins (PGRPs) are innate immune molecules with a diverse array of functions. In this issue of Cell Host & Microbe, Maillet and colleagues demonstrate that a Drosophila PGRP, PGRP-LF, functions as a negative regulator of the Drosophila immune deficiency (IMD) pathway, an innate immune signaling mechanism responsive to Gram-negative bacteria. PGRP-LF deficiency results in unregulated immune signaling, causing excessive antimicrobial peptide synthesis and, surprisingly, developmental defects.

Original languageEnglish (US)
Pages (from-to)273-274
Number of pages2
JournalCell Host and Microbe
Issue number5
StatePublished - May 15 2008

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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