Peptidoglycan recognition proteins: Modulators of the microbiome and inflammation

Research output: Contribution to journalReview article

181 Scopus citations

Abstract

All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules-the peptidoglycan recognition proteins-has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.

Original languageEnglish (US)
Pages (from-to)837-851
Number of pages15
JournalNature Reviews Immunology
Volume11
Issue number12
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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