Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-γ

Sukumar Saha, Xuefang Jing, Shin Yong Park, Shiyong Wang, Xinna Li, Dipika Gupta, Roman Dziarski

Research output: Contribution to journalArticle

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Abstract

There are multiple mechanisms that protect the intestine from an excessive inflammatory response to intestinal microorganisms. We report here that all four mammalian peptidoglycan recognition proteins (PGRPs or Pglyrps) protect the host from colitis induced by dextran sulfate sodium (DSS). Pglyrp1 -/-, Pglyrp2-/-, Pglyrp3-/-, and Pglyrp4 -/- mice are all more sensitive than wild-type mice to DSS-induced colitis due to a more inflammatory gut microflora, higher production of interferon-γ, higher expression of interferon-inducible genes, and an increased number of NK cells in the colon upon initial exposure to DSS, which leads to severe hyperplasia of the lamina propria, loss of epithelial cells, and ulceration in the colon. Thus, during experimental colitis, PGRPs protect the colon of wild-type mice from an early inflammatory response and the loss of the barrier function of intestinal epithelium by promoting normal bacterial flora and by preventing damaging production of interferon-γ by NK cells in response to injury.

Original languageEnglish
Pages (from-to)147-162
Number of pages16
JournalCell Host and Microbe
Volume8
Issue number2
DOIs
StatePublished - Aug 19 2010

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Dextran Sulfate
Colitis
Interferons
Colon
Natural Killer Cells
Intestinal Mucosa
Intestines
Hyperplasia
Mucous Membrane
Epithelial Cells
Wounds and Injuries
Genes
Gastrointestinal Microbiome
peptidoglycan recognition protein

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-γ. / Saha, Sukumar; Jing, Xuefang; Park, Shin Yong; Wang, Shiyong; Li, Xinna; Gupta, Dipika; Dziarski, Roman.

In: Cell Host and Microbe, Vol. 8, No. 2, 19.08.2010, p. 147-162.

Research output: Contribution to journalArticle

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