Percutaneous access

Acute effects on renal function and structure in a porcine model

Rajash Handa, Lynn R. Willis, Andrew Evan, Bret A. Connors, Jun Ying, William Fat-Anthony, Kelli R. Wind, Cynthia D. Johnson, Philip M. Blomgren, Mark C. Estrada, Ryan F. Paterson, Ramsay L. Kuo, Samuel C. Kim, Brian R. Matlaga, Nicole L. Miller, Stephanie L. Watkins, Shelly E. Handa, James E. Lingeman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages233-240
Number of pages8
Volume900
StatePublished - 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Fingerprint

renal function
kidneys
vasoconstriction
kidney stones
anions
ischemia
animals

Keywords

  • Kidney function
  • Percutaneous access
  • Percutaneous nephrolithotomy
  • Tract dilation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Handa, R., Willis, L. R., Evan, A., Connors, B. A., Ying, J., Fat-Anthony, W., ... Lingeman, J. E. (2007). Percutaneous access: Acute effects on renal function and structure in a porcine model. In AIP Conference Proceedings (Vol. 900, pp. 233-240)

Percutaneous access : Acute effects on renal function and structure in a porcine model. / Handa, Rajash; Willis, Lynn R.; Evan, Andrew; Connors, Bret A.; Ying, Jun; Fat-Anthony, William; Wind, Kelli R.; Johnson, Cynthia D.; Blomgren, Philip M.; Estrada, Mark C.; Paterson, Ryan F.; Kuo, Ramsay L.; Kim, Samuel C.; Matlaga, Brian R.; Miller, Nicole L.; Watkins, Stephanie L.; Handa, Shelly E.; Lingeman, James E.

AIP Conference Proceedings. Vol. 900 2007. p. 233-240.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Handa, R, Willis, LR, Evan, A, Connors, BA, Ying, J, Fat-Anthony, W, Wind, KR, Johnson, CD, Blomgren, PM, Estrada, MC, Paterson, RF, Kuo, RL, Kim, SC, Matlaga, BR, Miller, NL, Watkins, SL, Handa, SE & Lingeman, JE 2007, Percutaneous access: Acute effects on renal function and structure in a porcine model. in AIP Conference Proceedings. vol. 900, pp. 233-240, 1st Annual International Urolithiasis Research Symposium, Indianapolis, IN, United States, 11/2/06.
Handa R, Willis LR, Evan A, Connors BA, Ying J, Fat-Anthony W et al. Percutaneous access: Acute effects on renal function and structure in a porcine model. In AIP Conference Proceedings. Vol. 900. 2007. p. 233-240
Handa, Rajash ; Willis, Lynn R. ; Evan, Andrew ; Connors, Bret A. ; Ying, Jun ; Fat-Anthony, William ; Wind, Kelli R. ; Johnson, Cynthia D. ; Blomgren, Philip M. ; Estrada, Mark C. ; Paterson, Ryan F. ; Kuo, Ramsay L. ; Kim, Samuel C. ; Matlaga, Brian R. ; Miller, Nicole L. ; Watkins, Stephanie L. ; Handa, Shelly E. ; Lingeman, James E. / Percutaneous access : Acute effects on renal function and structure in a porcine model. AIP Conference Proceedings. Vol. 900 2007. pp. 233-240
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abstract = "Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.",
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AU - Ying, Jun

AU - Fat-Anthony, William

AU - Wind, Kelli R.

AU - Johnson, Cynthia D.

AU - Blomgren, Philip M.

AU - Estrada, Mark C.

AU - Paterson, Ryan F.

AU - Kuo, Ramsay L.

AU - Kim, Samuel C.

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AB - Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.

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