Percutaneous access: Acute effects on renal function and structure in a porcine model

Rajash K. Handa, Lynn R. Willis, Andrew P. Evan, Bret A. Connors, Jun Ying, William Fat-Anthony, Kelli R. Wind, Cynthia D. Johnson, Philip M. Blomgren, Mark C. Estrada, Ryan F. Paterson, Ramsay L. Kuo, Samuel C. Kim, Brian R. Matlaga, Nicole L. Miller, Stephanie L. Watkins, Shelly E. Handa, James E. Lingeman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
PublisherAmerican Institute of Physics Inc.
Pages233-240
Number of pages8
ISBN (Print)0735404062, 9780735404069
DOIs
StatePublished - Jan 1 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
Volume900
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Keywords

  • Kidney function
  • Percutaneous access
  • Percutaneous nephrolithotomy
  • Tract dilation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Handa, R. K., Willis, L. R., Evan, A. P., Connors, B. A., Ying, J., Fat-Anthony, W., Wind, K. R., Johnson, C. D., Blomgren, P. M., Estrada, M. C., Paterson, R. F., Kuo, R. L., Kim, S. C., Matlaga, B. R., Miller, N. L., Watkins, S. L., Handa, S. E., & Lingeman, J. E. (2007). Percutaneous access: Acute effects on renal function and structure in a porcine model. In RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium (pp. 233-240). (AIP Conference Proceedings; Vol. 900). American Institute of Physics Inc.. https://doi.org/10.1063/1.2723582