Performance evaluation of the new unicel DxH800 coulter cellular analysis system in a large hospital setting

Jacqueline Carr, Susan Geesaman, Magdalena Czader

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We evaluated the UniCel DxH 800 Coulter Cellular Analysis System, the newest-generation hematologic analyzer from Beckman Coulter, Inc, for its accuracy and clinical sensitivity. We compared the accuracy of the complete blood count (CBC), differential counts, nucleated red blood cell (NRBC) counts, and reticulocyte parameters from the DxH 800 system to that of the Coulter LH 750 Hematology Analyzer, and to manual differentials. The DxH 800 system provided accurate results for all analyzed parameters including the NRBC count, which correlated well with the manual NRBC count. With regard to flagged results, the DxH 800 was approximately 10% more efficient compared with the LH 750 analyzer. With our workload of more than 1500 samples per day, a 10% gain in overall efficiency will result in 30 fewer slides for review per day. The DxH 800 had a better negative predictive value (ie, 94% vs. 89%) and a better positive predictive value (ie, 40% vs. 34%). The DxH 800 system accurately counts CBCs, as well as differential and reticulocyte parameters. In this evaluation, we observed better clinical sensitivity in comparison with the LH 750 analyzer.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalLaboratory Medicine
Volume43
Issue number5
DOIs
StatePublished - Nov 26 2012

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Keywords

  • Complete blood count
  • DxH 800
  • High-throughput hematology analyzers
  • LH 750
  • NRBC

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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